Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

NCAN - neurocan

Homo sapiens

Synonyms: CSPG3, Chondroitin sulfate proteoglycan 3, NEUR, Neurocan core protein

Ostrowska, H. et al., Hartsell, W.F. et al.

Ostrowska, Krukowska, Kalinowska, Orłowska, Lengiewicz,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NCAN

In man, a deficiency of cathepsin A leads to a combined deficiency of beta-GAL and NEUR activities, called "galactosialidosis". Multiple mutations identified in the cathepsin A gene are the molecular basis of this lysosomal storage disease [1].

High impact information on NCAN

Children > or = 3 at diagnosis: 20 of 30 patients completed pre-CSI CH without progression; 15 are alive NED at 1.3-9.2 years, and 5 showed post-CSI progression in the PF (n = 3), in the NEUR (n = 1) and in bone marrow (n = 1) [2].

References

Lysosomal high molecular weight multienzyme complex. Ostrowska, H., Krukowska, K., Kalinowska, J., Orłowska, M., Lengiewicz, I. Cell. Mol. Biol. Lett. (2003) [Pubmed]
Patterns of failure in children with medulloblastoma: effects of preirradiation chemotherapy. Hartsell, W.F., Gajjar, A., Heideman, R.L., Langston, J.A., Sanford, R.A., Walter, A., Jones, D., Chen, G., Kun, L.E. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg