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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UNC45B  -  unc-45 homolog B (C. elegans)

Homo sapiens

Synonyms: CMYA4, Protein unc-45 homolog B, SMUNC45, UNC45, Unc-45B
 
 
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High impact information on UNC45B

  • These specialized co-chaperones include auxilin, cysteine string protein, Tom70, UNC-45 and homologs of Bag-1 [1].
  • We report here that mice and humans each have two genes that are located on different chromosomes, encode distinct UNC-45-like protein isoforms, and are expressed either in multiple tissues or only in cardiac and skeletal muscles [2].
  • The canonical UCS (UNC-45/Cro1/She4p) protein, Caenorhabditis elegans UNC-45, was one of the earliest molecules to be shown genetically to be necessary for sarcomere assembly [3].

References

  1. More than folding: localized functions of cytosolic chaperones. Young, J.C., Barral, J.M., Ulrich Hartl, F. Trends Biochem. Sci. (2003) [Pubmed]
  2. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. Price, M.G., Landsverk, M.L., Barral, J.M., Epstein, H.F. J. Cell. Sci. (2002) [Pubmed]
  3. The UCS family of myosin chaperones. Hutagalung, A.H., Landsverk, M.L., Price, M.G., Epstein, H.F. J. Cell. Sci. (2002) [Pubmed]
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