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Gene Review

DNAJC5  -  DnaJ (Hsp40) homolog, subfamily C, member 5

Homo sapiens

Synonyms: CLN4, CLN4B, CSP, Cysteine string protein, DNAJC5A, ...
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Disease relevance of DNAJC5

  • These results help to clarify previous experiments in which CSP, a purified LETS protein, partially restored a fibroblastic phenotype to cells transformed by tumor viruses [1].
  • Several studies, including AIDS Clinical Trials Group (ACTG) 116B/117, the Veterans Administration Study VA CSP 298 and, more recently, ACTG 175, have indicated that viral load monitoring is a powerful predictor of disease progression and clinical outcome [2].
  • Interstitial pneumonitis was more frequent among patients given ATG/CSP/MP [3].
  • METHODS: In this prospective, controlled study, 34 of the 72 consecutive patients with symptomatic uterovaginal prolapse were treated with colposacropexy with uterus conservation (hysterocolposacropexy, HSP) and the other 38 with hysterectomy followed by sacropexy (CSP) [4].
  • Recurrent low-grade cystoceles developed in 1/38 (2.6%) in the CSP group and in 5/34 (14.7%) in the HSP group (p=NS), recurrent low-grade rectocele developed in 6/38 (15.8%) and in 3/34 (8.8%) patients respectively (p=NS) [4].

Psychiatry related information on DNAJC5

  • HIV+ subjects with CSP were more likely to complain of sensory changes and performed more poorly on specific neuropsychological tests when compared with HIV+ subjects without CSP [5].

High impact information on DNAJC5


Biological context of DNAJC5


Anatomical context of DNAJC5


Associations of DNAJC5 with chemical compounds

  • Our results show that the guanine nucleotide exchange activity of full-length CSP is, in turn, regulated by Hsc70-SGT [19].
  • In addition, we provide an update on the mammalian isoforms of cysteine string protein following the recent discovery of two novel cysteine string proteins [16].
  • It is also notable that only 2 (5%) of 39 patients who received the combination of methotrexate and cyclosporine (MTX/CSP) for the prevention of GVHD developed grade II acute GVHD, and none developed grades III to IV acute GVHD [20].
  • In vitro 32P-phosphorylation studies revealed that Akt phosphorylates CSP on serine 10 [21].
  • Antipeptide antibodies against a Torpedo cysteine-string protein [22].

Physical interactions of DNAJC5


Other interactions of DNAJC5


Analytical, diagnostic and therapeutic context of DNAJC5

  • Both cysteine string protein (CSP) and soluble NSF attachment protein-alpha (alpha-SNAP) were phosphorylated by PKA in vitro, but immunoprecipitation of cellular alpha-SNAP failed to detect (32)P incorporation [13].
  • CSP #221 is a randomized multiinstitutional clinical trial to assess the efficacy of 10 d of perioperative total parenteral nutrition (TPN) in reducing morbidity and mortality in malnourished patients undergoing intraperitoneal and/or intrathoracic operations [25].
  • Given that further progress in instrumental design and engineering of dedicated, highly enantioselective CSPAs can be achieved, CPC may offer a viable alternative to CSP-based HPLC for preparative-scale enantiomer separation [26].
  • However, both a yeast-derived Ty virus-like particle expressing the optimal nine-amino acid epitope SYIPSAEKI from the CS protein (CSP-VLP) and a lipid-tailed peptide of this same sequence induced high levels of the major histocompatibility complex (MHC) class I-restricted CTL with one and three subcutaneous immunizations, respectively [27].
  • Electrical stimulation of both the dorsum and the palm evoked a CSP (latency 65 +/- 5 ms), although the reflex threshold was significantly lower after stimulation of the palm [28].


  1. Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines. Yamada, K.M., Yamada, S.S., Pastan, I. J. Cell Biol. (1977) [Pubmed]
  2. Correlation between viral load measurements and outcome in clinical trials of antiviral drugs. Schooley, R.T. AIDS (1995) [Pubmed]
  3. Treatment of human acute graft-versus-host disease with antithymocyte globulin and cyclosporine with or without methylprednisolone. Deeg, H.J., Loughran, T.P., Storb, R., Kennedy, M.S., Sullivan, K.M., Doney, K., Appelbaum, F.R., Thomas, E.D. Transplantation (1985) [Pubmed]
  4. Uterus preservation in surgical correction of urogenital prolapse. Costantini, E., Mearini, L., Bini, V., Zucchi, A., Mearini, E., Porena, M. Eur. Urol. (2005) [Pubmed]
  5. Increased prevalence of septal cavitation in a nonschizophrenic sample: an MRI study of HIV-infected individuals. Lalonde, F.M., Martin, A., Myslobodsky, M.S. The Journal of neuropsychiatry and clinical neurosciences. (1996) [Pubmed]
  6. Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Willingham, M.C., Yamada, K.M., Yamada, S.S., Pouysségur, J., Pastan, I. Cell (1977) [Pubmed]
  7. Neutralization of the infectivity of sporozoites of Plasmodium knowlesi by antibodies to a synthetic peptide. Gysin, J., Barnwell, J., Schlesinger, D.H., Nussenzweig, V., Nussenzweig, R.S. J. Exp. Med. (1984) [Pubmed]
  8. More than folding: localized functions of cytosolic chaperones. Young, J.C., Barral, J.M., Ulrich Hartl, F. Trends Biochem. Sci. (2003) [Pubmed]
  9. Immunological characterization of a major transformation-sensitive fibroblast cell surface glycoprotein. Localization, redistribution, and role in cell shape. Yamada, K.M. J. Cell Biol. (1978) [Pubmed]
  10. Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Yamada, K.M., Yamada, S.S., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  11. Mutational analysis of cysteine-string protein function in insulin exocytosis. Zhang, H., Kelley, W.L., Chamberlain, L.H., Burgoyne, R.D., Lang, J. J. Cell. Sci. (1999) [Pubmed]
  12. The multiple functions of cysteine-string protein analyzed at Drosophila nerve terminals. Bronk, P., Nie, Z., Klose, M.K., Dawson-Scully, K., Zhang, J., Robertson, R.M., Atwood, H.L., Zinsmaier, K.E. J. Neurosci. (2005) [Pubmed]
  13. Phosphorylation of cysteine string protein by protein kinase A. Implications for the modulation of exocytosis. Evans, G.J., Wilkinson, M.C., Graham, M.E., Turner, K.M., Chamberlain, L.H., Burgoyne, R.D., Morgan, A. J. Biol. Chem. (2001) [Pubmed]
  14. Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis. Zhang, H., Schmidt, B.Z., Sun, F., Condliffe, S.B., Butterworth, M.B., Youker, R.T., Brodsky, J.L., Aridor, M., Frizzell, R.A. J. Biol. Chem. (2006) [Pubmed]
  15. Association of L-glutamic acid decarboxylase to the 70-kDa heat shock protein as a potential anchoring mechanism to synaptic vesicles. Hsu, C.C., Davis, K.M., Jin, H., Foos, T., Floor, E., Chen, W., Tyburski, J.B., Yang, C.Y., Schloss, J.V., Wu, J.Y. J. Biol. Chem. (2000) [Pubmed]
  16. Tying everything together: the multiple roles of cysteine string protein (CSP) in regulated exocytosis. Evans, G.J., Morgan, A., Burgoyne, R.D. Traffic (2003) [Pubmed]
  17. Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. Boal, F., Le Pevelen, S., Cziepluch, C., Scotti, P., Lang, J. Biochim. Biophys. Acta (2007) [Pubmed]
  18. Abnormalities of the corpus callosum in nonpsychotic children with chromosome 22q11 deletion syndrome. Shashi, V., Muddasani, S., Santos, C.C., Berry, M.N., Kwapil, T.R., Lewandowski, E., Keshavan, M.S. Neuroimage (2004) [Pubmed]
  19. Characterization of the G alpha(s) regulator cysteine string protein. Natochin, M., Campbell, T.N., Barren, B., Miller, L.C., Hameed, S., Artemyev, N.O., Braun, J.E. J. Biol. Chem. (2005) [Pubmed]
  20. Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity. The Nagoya Bone Marrow Transplantation Group. Morishima, Y., Morishita, Y., Tanimoto, M., Ohno, R., Saito, H., Horibe, K., Hamajima, N., Naito, K., Yamada, K., Yokomaku, S. Blood (1989) [Pubmed]
  21. Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. Evans, G.J., Barclay, J.W., Prescott, G.R., Jo, S.R., Burgoyne, R.D., Birnbaum, M.J., Morgan, A. J. Biol. Chem. (2006) [Pubmed]
  22. Antipeptide antibodies against a Torpedo cysteine-string protein. Mastrogiacomo, A., Evans, C.J., Gundersen, C.B. J. Neurochem. (1994) [Pubmed]
  23. Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator. Zhang, H., Peters, K.W., Sun, F., Marino, C.R., Lang, J., Burgoyne, R.D., Frizzell, R.A. J. Biol. Chem. (2002) [Pubmed]
  24. Regulation of airway mucin secretion by MARCKS protein involves the chaperones heat shock protein 70 and cysteine string protein. Park, J., Fang, S., Adler, K.B. Proceedings of the American Thoracic Society. (2006) [Pubmed]
  25. Study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients. Buzby, G.P., Knox, L.S., Crosby, L.O., Eisenberg, J.M., Haakenson, C.M., McNeal, G.E., Page, C.P., Peterson, O.L., Reinhardt, G.F., Williford, W.O. Am. J. Clin. Nutr. (1988) [Pubmed]
  26. Preparative enantiomer separation of dichlorprop with a cinchona-derived chiral selector employing centrifugal partition chromatography and high-performance liquid chromatography: a comparative study. Gavioli, E., Maier, N.M., Minguillón, C., Lindner, W. Anal. Chem. (2004) [Pubmed]
  27. Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization. Allsopp, C.E., Plebanski, M., Gilbert, S., Sinden, R.E., Harris, S., Frankel, G., Dougan, G., Hioe, C., Nixon, D., Paoletti, E., Layton, G., Hill, A.V. Eur. J. Immunol. (1996) [Pubmed]
  28. Cutaneous silent period in hand muscle is evoked by laser stimulation of the palm, but not the hand dorsum. Romaniello, A., Truini, A., Galeotti, F., De Lena, C., Willer, J.C., Cruccu, G. Muscle Nerve (2004) [Pubmed]
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