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Gene Review:

MTH611 - prolyl-tRNA synthetase

Methanothermobacter thermautotrophicus str. Delta H

Praetorius-Ibba, M. et al.

Praetorius-Ibba, Rogers, Samson, Kelman, Ibba,

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High impact information on MTH611

No significant changes in the steady-state kinetics of LeuRS aminoacylation were observed upon the addition of ProRS [1].
These findings indicate that ProRS and LeuRS associate in M. thermautotrophicus and suggest that this interaction contributes to translational fidelity by enhancing tRNA aminoacylation by ProRS [1].

Associations of MTH611 with chemical compounds

Determination of the steady-state kinetics of tRNA(Pro) charging showed that the catalytic efficiency (k(cat)/K(m)) of ProRS increased 5-fold in the complex with LeuRS compared with the free enzyme, whereas the K(m) for proline was unchanged [1].

References

Association between Archaeal prolyl- and leucyl-tRNA synthetases enhances tRNA(Pro) aminoacylation. Praetorius-Ibba, M., Rogers, T.E., Samson, R., Kelman, Z., Ibba, M. J. Biol. Chem. (2005) [Pubmed]

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