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Gene Review:

APCDD1 - adenomatosis polyposis coli down-regulated 1

Homo sapiens

Synonyms: Adenomatosis polyposis coli down-regulated 1 protein, B7323, DRAPC1, FP7019, HHS, ...

Takahashi, M. et al., Jukkola, T. et al.

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Disease relevance of APCDD1

Moreover, we documented elevated expression of APCDD1 in 18 of 27 primary colon cancer tissues compared with corresponding noncancerous mucosae [1].

High impact information on APCDD1

Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis [1].
Exogenous APCDD1 promoted growth of colon cancer cells both in vitro and in vivo, whereas transfection with antisense S-oligodeoxynucleotides decreased cell/tumor growth [1].
We identified the mouse homolog of human DRAPC1 (APCDD1) gene, shown to be a target of Wnt/beta-catenin signaling pathway in cancer cell lines [2].

References

Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Takahashi, M., Fujita, M., Furukawa, Y., Hamamoto, R., Shimokawa, T., Miwa, N., Ogawa, M., Nakamura, Y. Cancer Res. (2002) [Pubmed]
Drapc1 expression during mouse embryonic development. Jukkola, T., Sinjushina, N., Partanen, J. Gene Expr. Patterns (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

APCDD1	Bos taurus
APCDD1	Canis lupus familiaris
LOC100332639	Danio rerio
APCDD1	Gallus gallus
APCDD1	Macaca mulatta
Apcdd1	Mus musculus
APCDD1	Pan troglodytes
Apcdd1	Rattus norvegicus
apcdd1	Xenopus (Silurana) tropicalis

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