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Gene Review

TCF7  -  transcription factor 7 (T-cell specific,...

Homo sapiens

Synonyms: T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, TCF1, ...
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Disease relevance of TCF7


High impact information on TCF7

  • A minimal common region of deletion was defined in 12q24 that included the gene TCF1 (transcription factor 1), encoding hepatocyte nuclear factor 1 (HNF1; refs 1,2) [6].
  • These results indicate that inactivation of TCF1, whether sporadic or associated with MODY3, is an important genetic event in the occurrence of human liver adenoma, and may be an early step in the development of some HCCs [6].
  • The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-specific activation of the T cell receptor (TCR) C alpha enhancer and binds to pyrimidine-rich elements (5'-PyCTTTG-3') present in a variety of other T cell-specific control regions [7].
  • Two mAb (HB57 and 5D7) that bound to distinct epitopes on IgM were highly effective initiators of B cell proliferation at very low concentrations, in the presence of a T cell factor source [8].
  • As a consequence of engaging the canonical Wnt pathway, a beta-catenin-T-cell factor (TCF) transcriptional complex is generated, which has been postulated to trigger the epithelial-mesenchymal transition (EMT) that characterizes the tissue-invasive phenotype [9].

Chemical compound and disease context of TCF7


Biological context of TCF7


Anatomical context of TCF7


Associations of TCF7 with chemical compounds


Physical interactions of TCF7

  • T-cell factor (TCF)-1 protein forms the transcriptional complex with beta-catenin and regulates the expression of diverse target genes during early development and carcinogenesis [24].
  • Nuclear beta-catenin enhances the activating expression of MMP-7 genes by binding with the T-cell factor/lymphoid enhancer factor family of transcription factors [25].
  • Based on a consensus TCF-binding sequence in the cyclin D1 and c-myc promoters, several double-stranded oligodeoxynucleotides were designed and tested for their ability to inhibit TCF activity in the HEK293 model [26].

Regulatory relationships of TCF7

  • HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4 [27].
  • Surprisingly we found that the LEF1 promoter is selectively activated by specific isoforms of the LEF/TCF transcription factor family that contain an alternative C-terminal "E" tail [28].
  • Consistent with the effect on fibrinogen adhesion, Ser(24) phosphorylation of DAB2 was also involved in the negative regulation of alpha(IIb)beta(3)-induced T cell factor transcriptional activity [29].
  • This is the first systematic study of the inhibitory effects of ACR, or any other retinoid compound, on beta-catenin/T-cell factor-stimulated cyclin D1 promoter activity in human tumor cells [30].

Other interactions of TCF7


Analytical, diagnostic and therapeutic context of TCF7


  1. Wnt activation and alternative promoter repression of LEF1 in colon cancer. Li, T.W., Ting, J.H., Yokoyama, N.N., Bernstein, A., van de Wetering, M., Waterman, M.L. Mol. Cell. Biol. (2006) [Pubmed]
  2. Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas. Zhai, Y., Wu, R., Schwartz, D.R., Darrah, D., Reed, H., Kolligs, F.T., Nieman, M.T., Fearon, E.R., Cho, K.R. Am. J. Pathol. (2002) [Pubmed]
  3. Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Salins, P., Shawesh, S., He, Y., Dibrov, A., Kashour, T., Arthur, G., Amara, F. Neurosci. Lett. (2007) [Pubmed]
  4. The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. Castrop, J., van Wichen, D., Koomans-Bitter, M., van de Wetering, M., de Weger, R., van Dongen, J., Clevers, H. Blood (1995) [Pubmed]
  5. Effective Treatment of Tumors with Strong {beta}-Catenin/T-Cell Factor Activity by Transcriptionally Targeted Oncolytic Herpes Simplex Virus Vector. Kuroda, T., Rabkin, S.D., Martuza, R.L. Cancer Res. (2006) [Pubmed]
  6. Bi-allelic inactivation of TCF1 in hepatic adenomas. Bluteau, O., Jeannot, E., Bioulac-Sage, P., Marqués, J.M., Blanc, J.F., Bui, H., Beaudoin, J.C., Franco, D., Balabaud, C., Laurent-Puig, P., Zucman-Rossi, J. Nat. Genet. (2002) [Pubmed]
  7. A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. Waterman, M.L., Fischer, W.H., Jones, K.A. Genes Dev. (1991) [Pubmed]
  8. Human B cell activation. Evidence for diverse signals provided by various monoclonal anti-IgM antibodies. Rudich, S.M., Winchester, R., Mongini, P.K. J. Exp. Med. (1985) [Pubmed]
  9. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Yook, J.I., Li, X.Y., Ota, I., Hu, C., Kim, H.S., Kim, N.H., Cha, S.Y., Ryu, J.K., Choi, Y.J., Kim, J., Fearon, E.R., Weiss, S.J. Nat. Cell Biol. (2006) [Pubmed]
  10. Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling. Xiang, D., Wang, D., He, Y., Xie, J., Zhong, Z., Li, Z., Xie, J. Anticancer Drugs (2006) [Pubmed]
  11. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Chakrabarty, S., Radjendirane, V., Appelman, H., Varani, J. Cancer Res. (2003) [Pubmed]
  12. Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. Hawcroft, G., D'Amico, M., Albanese, C., Markham, A.F., Pestell, R.G., Hull, M.A. Carcinogenesis (2002) [Pubmed]
  13. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Noble, J.A., White, A.M., Lazzeroni, L.C., Valdes, A.M., Mirel, D.B., Reynolds, R., Grupe, A., Aud, D., Peltz, G., Erlich, H.A. Diabetes (2003) [Pubmed]
  14. Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription. Tapia, J.C., Torres, V.A., Rodriguez, D.A., Leyton, L., Quest, A.F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  15. Ginsenoside-Rg1 Induces Vascular Endothelial Growth Factor Expression through the Glucocorticoid Receptor-related Phosphatidylinositol 3-Kinase/Akt and beta-Catenin/T-cell Factor-dependent Pathway in Human Endothelial Cells. Leung, K.W., Pon, Y.L., Wong, R.N., Wong, A.S. J. Biol. Chem. (2006) [Pubmed]
  16. Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. Willinger, T., Freeman, T., Herbert, M., Hasegawa, H., McMichael, A.J., Callan, M.F. J. Immunol. (2006) [Pubmed]
  17. Activation of the canonical wingless/t-cell factor signaling pathway promotes invasive differentiation of human trophoblast. Pollheimer, J., Loregger, T., Sonderegger, S., Saleh, L., Bauer, S., Bilban, M., Czerwenka, K., Husslein, P., Knöfler, M. Am. J. Pathol. (2006) [Pubmed]
  18. Gonadotropin-Induced Apoptosis in Human Ovarian Surface Epithelial Cells Is Associated with Cyclooxygenase-2 Up-Regulation via the {beta}-Catenin/T-Cell Factor Signaling Pathway. Pon, Y.L., Wong, A.S. Mol. Endocrinol. (2006) [Pubmed]
  19. Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. Teh, M.T., Blaydon, D., Ghali, L.R., Edmunds, S., Pantazi, E., Barnes, M.R., Leigh, I.M., Kelsell, D.P., Philpott, M.P. J. Cell. Sci. (2007) [Pubmed]
  20. Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells. Sakoguchi-Okada, N., Takahashi-Yanaga, F., Fukada, K., Shiraishi, F., Taba, Y., Miwa, Y., Morimoto, S., Iida, M., Sasaguri, T. Biochem. Pharmacol. (2007) [Pubmed]
  21. The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. Funato, Y., Michiue, T., Asashima, M., Miki, H. Nat. Cell Biol. (2006) [Pubmed]
  22. Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. Feng, Y., Bommer, G.T., Zhai, Y., Akyol, A., Hinoi, T., Winer, I., Lin, H.V., Cadigan, K.M., Cho, K.R., Fearon, E.R. Cancer Res. (2007) [Pubmed]
  23. Hot spots in Tcf4 for the interaction with beta-catenin. Fasolini, M., Wu, X., Flocco, M., Trosset, J.Y., Oppermann, U., Knapp, S. J. Biol. Chem. (2003) [Pubmed]
  24. Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer. Choi, K.H., Park, M.W., Lee, S.Y., Jeon, M.Y., Kim, M.Y., Lee, H.K., Yu, J., Kim, H.J., Han, K., Lee, H., Park, K., Park, W.J., Jeong, S. Mol. Cancer Ther. (2006) [Pubmed]
  25. Interrelation between expression of matrix metalloproteinase 7 and beta-catenin in esophageal cancer. Saeki, H., Tanaka, S., Sugimachi, K., Kimura, Y., Miyazaki, M., Ohga, T., Sugimachi, K. Dig. Dis. Sci. (2002) [Pubmed]
  26. Construction of a novel DNA decoy that inhibits the oncogenic {beta}-catenin/T-cell factor pathway. Seki, Y., Yamamoto, H., Yee Ngan, C., Yasui, M., Tomita, N., Kitani, K., Takemasa, I., Ikeda, M., Sekimoto, M., Matsuura, N., Albanese, C., Kaneda, Y., Pestell, R.G., Monden, M. Mol. Cancer Ther. (2006) [Pubmed]
  27. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. Jung, C., Kim, R.S., Lee, S.J., Wang, C., Jeng, M.H. Cancer Res. (2004) [Pubmed]
  28. A new beta-catenin-dependent activation domain in T cell factor. Atcha, F.A., Munguia, J.E., Li, T.W., Hovanes, K., Waterman, M.L. J. Biol. Chem. (2003) [Pubmed]
  29. Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling. Huang, C.L., Cheng, J.C., Liao, C.H., Stern, A., Hsieh, J.T., Wang, C.H., Hsu, H.L., Tseng, C.P. J. Biol. Chem. (2004) [Pubmed]
  30. Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. Suzui, M., Masuda, M., Lim, J.T., Albanese, C., Pestell, R.G., Weinstein, I.B. Cancer Res. (2002) [Pubmed]
  31. Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. Yasuda, J., Tsuchiya, A., Yamada, T., Sakamoto, M., Sekiya, T., Hirohashi, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  32. Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. Hlubek, F., Pfeiffer, S., Budczies, J., Spaderna, S., Jung, A., Kirchner, T., Brabletz, T. Br. J. Cancer (2006) [Pubmed]
  33. The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA. Mayer, K., Wolff, E., Clevers, H., Ballhausen, W.G. Biochim. Biophys. Acta (1995) [Pubmed]
  34. Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer. Lin, B.R., Chang, C.C., Che, T.F., Chen, S.T., Chen, R.J., Yang, C.Y., Jeng, Y.M., Liang, J.T., Lee, P.H., Chang, K.J., Chau, Y.P., Kuo, M.L. Gastroenterology (2005) [Pubmed]
  35. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Schwartz, D.R., Wu, R., Kardia, S.L., Levin, A.M., Huang, C.C., Shedden, K.A., Kuick, R., Misek, D.E., Hanash, S.M., Taylor, J.M., Reed, H., Hendrix, N., Zhai, Y., Fearon, E.R., Cho, K.R. Cancer Res. (2003) [Pubmed]
  36. Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Mizushima, T., Nakagawa, H., Kamberov, Y.G., Wilder, E.L., Klein, P.S., Rustgi, A.K. Cancer Res. (2002) [Pubmed]
  37. Suppression of gastric cancer cell growth by targeting the beta-catenin/T-cell factor pathway. Dvory-Sobol, H., Sagiv, E., Liberman, E., Kazanov, D., Arber, N. Cancer (2007) [Pubmed]
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