Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

dnaK - molecular chaperone DnaK

Methanosarcina mazei Go1

Clarens, M. et al., Thomsen, J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on dnaK

The CD spectra changed upon binding to the promoters of the stress genes grpE, dnaK, and dnaJ, with the changes being distinctive for each promoter; in contrast, no effect was produced by the promoter of a non-stress-gene [1].
The intergenic dnaK-dnaJ region contains inverted repeats [2].

Biological context of dnaK

The organization and expression of the first archeael dnaK-dnaJ gene cluster cloned and sequenced have been elucidated [2].
However, the archaeal genes also display characteristics that are distinct from those of eubacterial and eucaryotic homologs. dnaK and dnaJ are transcribed into monocistronic messages [2].

References

The basal transcription factors TBP and TFB from the mesophilic archaeon Methanosarcina mazeii: structure and conformational changes upon interaction with stress-gene promoters. Thomsen, J., De Biase, A., Kaczanowski, S., Macario, A.J., Thomm, M., Zielenkiewicz, P., MacColl, R., Conway de Macario, E. J. Mol. Biol. (2001) [Pubmed]
The archaeal dnaK-dnaJ gene cluster: organization and expression in the methanogen Methanosarcina mazei. Clarens, M., Macario, A.J., Conway de Macario, E. J. Mol. Biol. (1995) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.