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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Archaeal

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Disease relevance of Genes, Archaeal

  • Here, we report that some of the Rosetta strains of E. coli, which harbour the rare tRNA genes for the expression of archaeal genes, favour semi-anaerobic conditions for the expression of putative FMN binding domain of glutamate synthase from Methanocaldococcus jannaschii at low inducer concentrations [1].

High impact information on Genes, Archaeal

  • The protein translations of these two archaeal genes in turn are homologs of a small subunit found in eukaryotic RNA polymerase I (A12.2) and the counterpart of this from RNA polymerase II (B12.6) [2].
  • DNA binding studies indicate that S.shibatae TBP recognizes TATA-like A-box sequences that are present upstream of most archaeal genes [3].
  • Here we screened 16 strains from the genus Thermotoga and other related Thermotogales for the occurrence of two of these "archaeal" genes: the gene encoding the large subunit of glutamate synthase (gltB) and the myo-inositol 1P synthase gene (ino1) [4].
  • However, the archaeal genes also display characteristics that are distinct from those of eubacterial and eucaryotic homologs. dnaK and dnaJ are transcribed into monocistronic messages [5].
  • We identified the first archaeal tRNA ribose 2'-O-methylase, aTrm56, belonging to the Cluster of Orthologous Groups (COG) 1303 that contains archaeal genes only [6].

Associations of Genes, Archaeal with chemical compounds

  • Only the relative abundance of Methanosarcinaceae (182 bp) increased, roughly doubling from 15 to 29% of total archaeal gene frequency within the first 11 days, which was positively correlated to the dynamics of acetate and formate concentrations [7].

Gene context of Genes, Archaeal

  • This paper reports the identification of an archaeal gene encoding a new nucleotidyltransferase, which is proposed to be the nonorthologous replacement of the S. enterica cobU gene [8].
  • An archaeal gene upstream of grpE different from eubacterial counterparts [9].
  • Phylogenetic analyses of HMG-CoA reductase protein sequences suggested that the two archaeal genes are distant homologs of eukaryotic genes [10].
  • The archaeal SOR provides a novel mechanism to reduce superoxide and demonstrates the potential for using archaeal genes to alter eukaryotic metabolism [11].


  1. Semi-anaerobic Growth Conditions are Favoured by some Escherichia coli Strains During Heterologous Expression of Some Archaeal Proteins. Demir, V., Dincturk, H.B. Mol. Biol. Rep. (2006) [Pubmed]
  2. The sequence, and its evolutionary implications, of a Thermococcus celer protein associated with transcription. Kaine, B.P., Mehr, I.J., Woese, C.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Cloning and functional analysis of the TATA binding protein from Sulfolobus shibatae. Qureshi, S.A., Baumann, P., Rowlands, T., Khoo, B., Jackson, S.P. Nucleic Acids Res. (1995) [Pubmed]
  4. Phylogenetic analyses of two "archaeal" genes in thermotoga maritima reveal multiple transfers between archaea and bacteria. Nesbo, C.L., L'Haridon, S., Stetter, K.O., Doolittle, W.F. Mol. Biol. Evol. (2001) [Pubmed]
  5. The archaeal dnaK-dnaJ gene cluster: organization and expression in the methanogen Methanosarcina mazei. Clarens, M., Macario, A.J., Conway de Macario, E. J. Mol. Biol. (1995) [Pubmed]
  6. The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP. Renalier, M.H., Joseph, N., Gaspin, C., Thebault, P., Mougin, A. RNA (2005) [Pubmed]
  7. Archaeal population dynamics during sequential reduction processes in rice field soil. Lueders, T., Friedrich, M. Appl. Environ. Microbiol. (2000) [Pubmed]
  8. Identification of an alternative nucleoside triphosphate: 5'-deoxyadenosylcobinamide phosphate nucleotidyltransferase in Methanobacterium thermoautotrophicum delta H. Thomas, M.G., Escalante-Semerena, J.C. J. Bacteriol. (2000) [Pubmed]
  9. An archaeal gene upstream of grpE different from eubacterial counterparts. Macario, A.J., Simon, V.H., Conway de Macario, E. Biochim. Biophys. Acta (1995) [Pubmed]
  10. 3-hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product. Bochar, D.A., Brown, J.R., Doolittle, W.F., Klenk, H.P., Lam, W., Schenk, M.E., Stauffacher, C.V., Rodwell, V.W. J. Bacteriol. (1997) [Pubmed]
  11. Production of a thermostable archaeal superoxide reductase in plant cells. Im, Y.J., Ji, M., Lee, A.M., Boss, W.F., Grunden, A.M. FEBS Lett. (2005) [Pubmed]
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