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Gene Review

UL44  -  dsDNA-binding protein; involved in DNA...

Human herpesvirus 5

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Disease relevance of HHV5gp049

 

High impact information on HHV5gp049

  • From approximately 50,000 small molecules, we identified 5 structurally diverse compounds that not only specifically interfere with this interaction, but also with the physical and functional interaction of UL44 with full-length catalytic subunit [2].
  • We next showed that recombinant HCMV UL44, but not human herpesvirus type 6 p41, which lacks the RGD motif, could mediate cell adhesion in a similar manner [3].

References

  1. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Appleton, B.A., Loregian, A., Filman, D.J., Coen, D.M., Hogle, J.M. Mol. Cell (2004) [Pubmed]
  2. Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Loregian, A., Coen, D.M. Chem. Biol. (2006) [Pubmed]
  3. The RGD sequence in the cytomegalovirus DNA polymerase accessory protein can mediate cell adhesion. Loh, L.C., Locke, D., Melnychuk, R., Lafert, n.u.l.l. Virology (2000) [Pubmed]
 
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