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Gene Review:

GSHVgp3 - pre-surface antigen

Ground squirrel hepatitis virus

Laub, O. et al., Galle, P.R. et al.

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Disease relevance of GSHVgp3

Whereas expression of duck hepatitis B pre-surface antigen was constant during this time, expression of duck hepatitis B core antigen and of viral DNA rapidly declined [1].

High impact information on GSHVgp3

RNA mapping studies suggest that the transcription of the HBsAg gene is initiated at more than one site, or alternatively, that RNA splicing of transcripts occurs in the pre-surface antigen region [2].

References

Replication of duck hepatitis B virus in primary duck hepatocytes and its dependence on the state of differentiation of the host cell. Galle, P.R., Schlicht, H.J., Kuhn, C., Schaller, H. Hepatology (1989) [Pubmed]
Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region. Laub, O., Rall, L.B., Truett, M., Shaul, Y., Standring, D.N., Valenzuela, P., Rutter, W.J. J. Virol. (1983) [Pubmed]

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