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Gene Review:

VP1 -

Canine parvovirus

Guo, Y. et al., Hirasawa, T. et al.

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Disease relevance of VP1

The other foreign gene, canine parvovirus type 2 (CPV-2) VP1 could not be sub-cloned into the vector and amplified without mutation (frame shift mutation) [1].
During the plasmid amplification stage, an unexpected expression of the CPV-2 VP1 gene (not in the target plants, but in E. coli) can interrupt the downstream work [1].

High impact information on VP1

The sequences of the PCR primer pairs were selected from the conserved region in the CPV VP1/VP2 gene [2].

References

A cryptic promoter in potato virus X vector interrupted plasmid construction. Guo, Y., German, T.L., Schultz, R.D. BMC Mol. Biol. (2007) [Pubmed]
Sensitive detection of canine parvovirus DNA by the nested polymerase chain reaction. Hirasawa, T., Kaneshige, T., Mikazuki, K. Vet. Microbiol. (1994) [Pubmed]

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