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Gene Review:

NS1 - NS1

Human respiratory syncytial virus

Valarcher, J.F. et al., Hengst, U. et al., Randhawa, J.S. et al.

Valarcher, Furze, Wyld, Cook, Conzelmann, Taylor,

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Disease relevance of NS1

Domains of human respiratory syncytial virus P protein essential for homodimerization and for binding to N and NS1 protein [1].

High impact information on NS1

The greater level of protection induced by the NS2, than by the NS1, deletion mutant, was associated with higher BRSV-specific antibody titers and greater priming of BRSV-specific, IFN-gamma-producing CD4(+) T cells [2].
Furthermore, this confirms the absence of the NS1 and NS2 gene analogs within the APV genome [3].

References

Domains of human respiratory syncytial virus P protein essential for homodimerization and for binding to N and NS1 protein. Hengst, U., Kiefer, P. Virus Genes (2000) [Pubmed]
Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins. Valarcher, J.F., Furze, J., Wyld, S., Cook, R., Conzelmann, K.K., Taylor, G. J. Virol. (2003) [Pubmed]
Rescue of synthetic minireplicons establishes the absence of the NS1 and NS2 genes from avian pneumovirus. Randhawa, J.S., Marriott, A.C., Pringle, C.R., Easton, A.J. J. Virol. (1997) [Pubmed]

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