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taf  -  taf

Simian foamy virus

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Disease relevance of taf


High impact information on taf

  • One of these open reading frames is a viral transactivator, encoded by genes designated taf for SFV and bel-1 for HFV, which augments transcription directed by the long terminal repeat (LTR) through cis-acting targets in the U3 domain of the LTR [4].
  • No significant nucleotide sequence homology between these two regions is noted; thus, the SFV-1 taf gene acts through at least two distinct sequence elements in the LTR [2].
  • Amino acid homologies between corresponding genes of SFVcpz and HFV range between 86% for the taf gene and 95% for the pol gene [5].
  • These target sequences for taf confer responsiveness to a heterologous promoter independent of orientation; thus, they function like conditional enhancers [1].
  • The taf responsive elements have been mapped to the U3 region of the LTR, between positions -637 and -180 (+1 represents the transcription initiation site) [1].

Biological context of taf


  1. Regulatory elements in the long terminal repeat (LTR) of simian foamy virus type 3 (SFV-3). Renne, R., Mergia, A., Renshaw-Gegg, L.W., Neumann-Haefelin, D., Luciw, P.A. Virology (1993) [Pubmed]
  2. cis-acting regulatory regions in the long terminal repeat of simian foamy virus type 1. Mergia, A., Pratt-Lowe, E., Shaw, K.E., Renshaw-Gegg, L.W., Luciw, P.A. J. Virol. (1992) [Pubmed]
  3. Sites of simian foamy virus persistence in naturally infected African green monkeys: latent provirus is ubiquitous, whereas viral replication is restricted to the oral mucosa. Falcone, V., Leupold, J., Clotten, J., Urbanyi, E., Herchenröder, O., Spatz, W., Volk, B., Böhm, N., Toniolo, A., Neumann-Haefelin, D., Schweizer, M. Virology (1999) [Pubmed]
  4. Characterization of the internal promoter of simian foamy viruses. Campbell, M., Renshaw-Gegg, L., Renne, R., Luciw, P.A. J. Virol. (1994) [Pubmed]
  5. Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV). Herchenröder, O., Renne, R., Loncar, D., Cobb, E.K., Murthy, K.K., Schneider, J., Mergia, A., Luciw, P.A. Virology (1994) [Pubmed]
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