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Gene Review:

M - gp18

Borna disease virus

Kraus, I. et al., Pyper, J.M. et al., Kliche, S. et al., Schneider, P.A. et al.

Pyper, Clements, Zink,

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Disease relevance of M

Characterization of a Borna disease virus glycoprotein, gp18 [1].
Nucleoli isolated from persistently infected neuroblastoma cells contained both genomic and antigenomic BDV RNA species as well as an enrichment of the 39/38-kDa and gp18 BDV proteins [2].

High impact information on M

The open reading frame III of Borna disease virus (BDV) codes for a protein with a mass of 16 kDa, named p16 or BDV-M. p16 was described as an N-glycosylated protein in several previous publications and therefore was termed gp18, although the amino acid sequence of p16 does not contain any regular consensus sequence for N glycosylation [3].
Products have been reported only for ORFs I, II, and III, encoding N (p40), P (p24/p23), and M (gp18), respectively [4].
Lectin binding and endoglycosidase sensitivity assays indicate that gp18 is an unusual N-linked glycoprotein [1].

References

Characterization of a Borna disease virus glycoprotein, gp18. Kliche, S., Briese, T., Henschen, A.H., Stitz, L., Lipkin, W.I. J. Virol. (1994) [Pubmed]
The nucleolus is the site of Borna disease virus RNA transcription and replication. Pyper, J.M., Clements, J.E., Zink, M.C. J. Virol. (1998) [Pubmed]
Open reading frame III of borna disease virus encodes a nonglycosylated matrix protein. Kraus, I., Eickmann, M., Kiermayer, S., Scheffczik, H., Fluess, M., Richt, J.A., Garten, W. J. Virol. (2001) [Pubmed]
Biochemical and functional analysis of the Borna disease virus G protein. Schneider, P.A., Hatalski, C.G., Lewis, A.J., Lipkin, W.I. J. Virol. (1997) [Pubmed]

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