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MeSH Review

Borna Disease

 
 
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Disease relevance of Borna Disease

  • Orofacial dyskinesias and dystonia in rats infected with Borna disease virus; a model for tardive dyskinetic syndromes [1].
  • These findings support the hypothesis that Borna disease virus is a negative-strand RNA virus and suggest that p40 is involved in transcription and/or replication [2].
  • Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis [3].
  • The highly attenuated Orf virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus, which represents a major antigen for the induction of a Borna disease virus-specific humoral and cellular immune response [4].
  • OBJECTIVE: The purpose of this study was to look for Borna disease virus (BDV) in 18 patients with acute onset of fibromyalgia (FMS) following a "flu-like" episode [5].
 

High impact information on Borna Disease

  • Depression, Borna disease, and amantadine [6].
  • The active polymerase complex of Borna disease virus is composed of the viral proteins N, P, and L [7].
  • Overlap of interaction domains indicates a central role of the P protein in assembly and regulation of the Borna disease virus polymerase complex [7].
  • Characterization of an unusual importin alpha binding motif in the borna disease virus p10 protein that directs nuclear import [8].
  • To determine whether this is a reflection of the physiological contribution of ONOO(-) to an immune response against a neurotropic pathogen, we have assessed the effects on adult rats acutely infected with Borna disease virus (BDV) of administration of uric acid (UA), an inhibitor of select chemical reactions associated with ONOO(-) [9].
 

Chemical compound and disease context of Borna Disease

 

Biological context of Borna Disease

 

Anatomical context of Borna Disease

 

Gene context of Borna Disease

 

Analytical, diagnostic and therapeutic context of Borna Disease

References

  1. Orofacial dyskinesias and dystonia in rats infected with Borna disease virus; a model for tardive dyskinetic syndromes. Solbrig, M., Koob, G., Lipkin, W. Mol. Psychiatry (1999) [Pubmed]
  2. Sequence similarity between Borna disease virus p40 and a duplicated domain within the paramyxovirus and rhabdovirus polymerase proteins. McClure, M.A., Thibault, K.J., Hatalski, C.G., Lipkin, W.I. J. Virol. (1992) [Pubmed]
  3. Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis. Furrer, E., Bilzer, T., Stitz, L., Planz, O. J. Virol. (2001) [Pubmed]
  4. Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant. Henkel, M., Planz, O., Fischer, T., Stitz, L., Rziha, H.J. J. Virol. (2005) [Pubmed]
  5. Search for Borna disease virus in Danish fibromyalgia patients. Wittrup, I.H., Christensen, L.S., Jensen, B., Danneskiold-Samsee, B., Bliddal, H., Wiik, A. Scand. J. Rheumatol. (2000) [Pubmed]
  6. Depression, Borna disease, and amantadine. Lieb, K., Hufert, F.T., Bechter, K., Bauer, J., Kornhuber, J. Lancet (1997) [Pubmed]
  7. Overlap of interaction domains indicates a central role of the P protein in assembly and regulation of the Borna disease virus polymerase complex. Schneider, U., Blechschmidt, K., Schwemmle, M., Staeheli, P. J. Biol. Chem. (2004) [Pubmed]
  8. Characterization of an unusual importin alpha binding motif in the borna disease virus p10 protein that directs nuclear import. Wolff, T., Unterstab, G., Heins, G., Richt, J.A., Kann, M. J. Biol. Chem. (2002) [Pubmed]
  9. The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent. Hooper, D.C., Kean, R.B., Scott, G.S., Spitsin, S.V., Mikheeva, T., Morimoto, K., Bette, M., Röhrenbeck, A.M., Dietzschold, B., Weihe, E. J. Immunol. (2001) [Pubmed]
  10. Borna disease virus glycoprotein is required for viral dissemination in neurons. Bajramovic, J.J., Münter, S., Syan, S., Nehrbass, U., Brahic, M., Gonzalez-Dunia, D. J. Virol. (2003) [Pubmed]
  11. Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus. Volmer, R., Bajramovic, J.J., Schneider, U., Ufano, S., Pochet, S., Gonzalez-Dunia, D. J. Virol. (2005) [Pubmed]
  12. Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in cyclosporine A-treated, immunosuppressed rats. Stitz, L., Schilken, D., Frese, K. J. Virol. (1991) [Pubmed]
  13. Two proline-rich nuclear localization signals in the amino- and carboxyl-terminal regions of the Borna disease virus phosphoprotein. Shoya, Y., Kobayashi, T., Koda, T., Ikuta, K., Kakinuma, M., Kishi, M. J. Virol. (1998) [Pubmed]
  14. A methionine-rich domain mediates CRM1-dependent nuclear export activity of Borna disease virus phosphoprotein. Yanai, H., Kobayashi, T., Hayashi, Y., Watanabe, Y., Ohtaki, N., Zhang, G., de la Torre, J.C., Ikuta, K., Tomonaga, K. J. Virol. (2006) [Pubmed]
  15. 1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread. Bajramovic, J.J., Syan, S., Brahic, M., de la Torre, J.C., Gonzalez-Dunia, D. J. Virol. (2002) [Pubmed]
  16. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. Sauder, C., Hallensleben, W., Pagenstecher, A., Schneckenburger, S., Biro, L., Pertlik, D., Hausmann, J., Suter, M., Staeheli, P. J. Virol. (2000) [Pubmed]
  17. Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin. Richt, J.A., Fürbringer, T., Koch, A., Pfeuffer, I., Herden, C., Bause-Niedrig, I., Garten, W. J. Virol. (1998) [Pubmed]
  18. Upregulation of COX-2 and CGRP expression in resident cells of the Borna disease virus-infected brain is dependent upon inflammation. Röhrenbeck, A.M., Bette, M., Hooper, D.C., Nyberg, F., Eiden, L.E., Dietzschold, B., Weihe, E. Neurobiol. Dis. (1999) [Pubmed]
  19. CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin. Hausmann, J., Schamel, K., Staeheli, P. J. Virol. (2001) [Pubmed]
  20. Characterization of Borna disease virus p56 protein, a surface glycoprotein involved in virus entry. Gonzalez-Dunia, D., Cubitt, B., Grasser, F.A., de la Torre, J.C. J. Virol. (1997) [Pubmed]
  21. Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1. Zhang, G., Kobayashi, T., Kamitani, W., Komoto, S., Yamashita, M., Baba, S., Yanai, H., Ikuta, K., Tomonaga, K. J. Virol. (2003) [Pubmed]
  22. A short leucine-rich sequence in the Borna disease virus p10 protein mediates association with the viral phospho- and nucleoproteins. Wolff, T., Pfleger, R., Wehner, T., Reinhardt, J., Richt, J.A. J. Gen. Virol. (2000) [Pubmed]
  23. Transforming growth factor-beta modulates T cell-mediated encephalitis caused by Borna disease virus. Pathogenic importance of CD8+ cells and suppression of antibody formation. Stitz, L., Planz, O., Bilzer, T., Frei, K., Fontana, A. J. Immunol. (1991) [Pubmed]
  24. Detection of Borna disease virus RNA in formalin-fixed, paraffin-embedded brain tissues by nested PCR. Sorg, I., Metzler, A. J. Clin. Microbiol. (1995) [Pubmed]
  25. Molecular ratio between borna disease viral-p40 and -p24 proteins in infected cells determined by quantitative antigen capture ELISA. Watanabe, M., Zhong, Q., Kobayashi, T., Kamitani, W., Tomonaga, K., Ikuta, K. Microbiol. Immunol. (2000) [Pubmed]
  26. Antibodies to Borna disease virus in infected adult rats: an early appearance of anti-p10 antibody and recognition of novel virus-specific proteins in infected animal brain cells. Watanabe, M., Kobayashi, T., Tomonaga, K., Ikuta, K. J. Vet. Med. Sci. (2000) [Pubmed]
 
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