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Gene Review

G  -  57 kDa ORF

Borna disease virus

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Disease relevance of G


High impact information on G

  • Borna disease virus glycoprotein is required for viral dissemination in neurons [5].
  • We assessed whether the viral envelope glycoprotein (GP) is required for neuronal dissemination of BDV by using primary cultures of rat hippocampal neurons [5].
  • Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes [6].
  • In concert these findings indicate that ORF IV encodes a 94-kDa N-linked glycoprotein with extensive high mannose- and/or hybrid-type oligosaccharide modifications [7].
  • Whereas the N and P ORFs are translated from monocistronic transcripts, the M, G, and pol ORFs are translated from polycistronic transcripts [8].

Chemical compound and disease context of G

  • The only surface membrane glycoprotein of Borna disease virus (BDV) is synthesized as a polypeptide with a molecular mass of 57 kDa and N-glycosylated to a precursor glycoprotein (GP) of about 94 kDa [9].

Biological context of G


Anatomical context of G


Other interactions of G

  • Lectin binding and endoglycosidase sensitivity assays indicate that gp18 is an unusual N-linked glycoprotein [17].

Analytical, diagnostic and therapeutic context of G

  • The complex-trapping-blocking (CTB) ELISA for detection of antibodies against classical swine fever virus (CSFV) using two monoclonal antibodies (mAbs) directed against envelope glycoprotein E2, has been improved using recombinant CSFV E2-antigen [18].


  1. Characterization of Borna disease virus p56 protein, a surface glycoprotein involved in virus entry. Gonzalez-Dunia, D., Cubitt, B., Grasser, F.A., de la Torre, J.C. J. Virol. (1997) [Pubmed]
  2. Deletions of structural glycoprotein E2 of classical swine fever virus strain alfort/187 resolve a linear epitope of monoclonal antibody WH303 and the minimal N-terminal domain essential for binding immunoglobulin G antibodies of a pig hyperimmune serum. Lin, M., Lin, F., Mallory, M., Clavijo, A. J. Virol. (2000) [Pubmed]
  3. Subdivision of the pestivirus genus based on envelope glycoprotein E2. van Rijn, P.A., van Gennip, H.G., Leendertse, C.H., Bruschke, C.J., Paton, D.J., Moormann, R.J., van Oirschot, J.T. Virology (1997) [Pubmed]
  4. Maturation of Borna disease virus glycoprotein. Eickmann, M., Kiermayer, S., Kraus, I., Gössl, M., Richt, J.A., Garten, W. FEBS Lett. (2005) [Pubmed]
  5. Borna disease virus glycoprotein is required for viral dissemination in neurons. Bajramovic, J.J., Münter, S., Syan, S., Nehrbass, U., Brahic, M., Gonzalez-Dunia, D. J. Virol. (2003) [Pubmed]
  6. Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes. Nishino, Y., Kobasa, D., Rubin, S.A., Pletnikov, M.V., Carbone, K.M. J. Virol. (2002) [Pubmed]
  7. Biochemical and functional analysis of the Borna disease virus G protein. Schneider, P.A., Hatalski, C.G., Lewis, A.J., Lipkin, W.I. J. Virol. (1997) [Pubmed]
  8. Evidence for translation of the Borna disease virus G protein by leaky ribosomal scanning and ribosomal reinitiation. Schneider, P.A., Kim, R., Lipkin, W.I. J. Virol. (1997) [Pubmed]
  9. Identification of the amino terminal subunit of the glycoprotein of Borna disease virus. Kiermayer, S., Kraus, I., Richt, J.A., Garten, W., Eickmann, M. FEBS Lett. (2002) [Pubmed]
  10. Implication of a cis-acting element in the cytoplasmic accumulation of unspliced Borna disease virus RNAs. Schneider, P.A., Schwemmle, M., Lipkin, W.I. J. Virol. (1997) [Pubmed]
  11. Presumptive diagnostic differentiation of hog cholera virus from bovine viral diarrhea and border disease viruses by using a cDNA nested-amplification approach. Katz, J.B., Ridpath, J.F., Bolin, S.R. J. Clin. Microbiol. (1993) [Pubmed]
  12. Identification of a novel virulence determinant within the E2 structural glycoprotein of classical swine fever virus. Risatti, G.R., Holinka, L.G., Carrillo, C., Kutish, G.F., Lu, Z., Tulman, E.R., Sainz, I.F., Borca, M.V. Virology (2006) [Pubmed]
  13. The envelope glycoprotein E2 is a determinant of cell culture tropism in ruminant pestiviruses. Liang, D., Sainz, I.F., Ansari, I.H., Gil, L.H., Vassilev, V., Donis, R.O. J. Gen. Virol. (2003) [Pubmed]
  14. Inhibition of Borna disease virus-mediated cell fusion by monoclonal antibodies directed against the viral glycoprotein. Furrer, E., Planz, O., Stitz, L. Intervirology (2004) [Pubmed]
  15. Border disease. Virus-induced decrease in thyroid hormone levels with associated hypomyelination. Anderson, C.A., Higgins, R.J., Smith, M.E., Osburn, B.I. Lab. Invest. (1987) [Pubmed]
  16. Tropism of border disease virus for oligodendrocytes in ovine fetal brain cell cultures. Anderson, C.A., Higgins, R.J., Waldvogel, A.S., Osburn, B.I. Am. J. Vet. Res. (1987) [Pubmed]
  17. Characterization of a Borna disease virus glycoprotein, gp18. Kliche, S., Briese, T., Henschen, A.H., Stitz, L., Lipkin, W.I. J. Virol. (1994) [Pubmed]
  18. An improved ELISA for the detection of serum antibodies directed against classical swine fever virus. Colijn, E.O., Bloemraad, M., Wensvoort, G. Vet. Microbiol. (1997) [Pubmed]
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