Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PYHIN1 - pyrin and HIN domain family, member 1

Homo sapiens

Synonyms: IFIX, Interferon-inducible protein X, MGC23885, Pyrin and HIN domain-containing protein 1

Ding, Y. et al., Ding, Y. et al.

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Disease relevance of PYHIN1

IFIX is the newest member of the human HIN-200 family and is often downregulated in breast tumors and breast cancer cell lines [1].

High impact information on PYHIN1

Finally, we show that IFIX mediates HDM2 downregulation in an IFN-inducible system [1].
We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the 200-amino-acid repeat (HIN-200) family [2].

References

Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. Ding, Y., Lee, J.F., Lu, H., Lee, M.H., Yan, D.H. Mol. Cell. Biol. (2006) [Pubmed]
Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Ding, Y., Wang, L., Su, L.K., Frey, J.A., Shao, R., Hunt, K.K., Yan, D.H. Oncogene (2004) [Pubmed]

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