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Gene Review

Hist4  -  histone cluster 4

Mus musculus

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High impact information on Hist4

  • We show that other heterochromatic marks, such as histone 3 Lys 9 (H3K9) and histone 4 Lys 20 (H4K20) trimethylation, remain at both subtelomeric and telomeric regions in these cells [1].
  • We found a greatly reduced histone 3 and histone 4 acetylation level in IL-7Ralpha(-/-) thymocytes in comparison with RAG(-/-) thymocytes or fetal thymocytes [2].
  • Mouse L cells were treated with either tetranitromethane (TNM) or ultraviolet (uv) light at 280 nm in order to induce the cross-linking of histone 2B in their chromatin to either histone 4 or 2A [3].

References

  1. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Gonzalo, S., Jaco, I., Fraga, M.F., Chen, T., Li, E., Esteller, M., Blasco, M.A. Nat. Cell Biol. (2006) [Pubmed]
  2. Cutting edge: histone acetylation and recombination at the TCR gamma locus follows IL-7 induction. Huang, J., Durum, S.K., Muegge, K. J. Immunol. (2001) [Pubmed]
  3. Histone-histone interactions within chromatin. Preliminary characterization of presumptive H2B-H2A and H2B-H4 binding. Martinson, H.G., McCarthy, B.J. Biochemistry (1976) [Pubmed]
 
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