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Gene Review

Il7r  -  interleukin 7 receptor

Mus musculus

Synonyms: CD127, IL-7 receptor alpha chain, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, ...
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Disease relevance of Il7r


High impact information on Il7r


Biological context of Il7r


Anatomical context of Il7r


Associations of Il7r with chemical compounds


Physical interactions of Il7r


Regulatory relationships of Il7r

  • This was found to be due to competition between DN and IL-7R-expressing DP cells for endogenous IL-7, which resulted in decreased levels of Bcl-2 in DN cells, increased DN apoptosis, and decreased DN cell number [12].
  • Promoter and chromatin crosslinking analyses suggest that PU.1 directly regulates transcription of the IL-7Ralpha gene [18].
  • The absence of contraction correlated with decreased early inflammation and interferon-gamma production and an increased fraction of CD8(+) T cells expressing the interleukin 7 receptor at the peak of the response [19].
  • The rare DPhic-Kit- blast cells that thus are salvaged for positive selection by expressing a self-major histocompatibility complex selectable TCRalpha/beta up-regulate IL-7R, but not c-Kit, and are the principal progenitors on the c-Kit- pathway; this c-Kit-IL-7R+ pathway is mainly CD4 lineage committed [20].

Other interactions of Il7r

  • Intestinal IL-7Ralpha+ cells are lymphoid in morphology but CD3(-) and functional in both nu/nu and Rag2-/- mice [14].
  • Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development [9].
  • In contrast, no VCAM-1+ spots were detected in the embryonic nor neonatal il7ralpha-/- mice, suggesting that IL-7Ralpha signal is involved in the early phase of PP anlage formation [21].
  • Furthermore, CXCL13 was found to be sufficient to mediate CD4+ CD3- IL-7R alpha hi cell recruitment in vivo to an ectopic site [22].
  • In addition to the appearance of VCAM1+ spots, the clustering of IL-7Ralpha+ cells was absent in the jak3-/- mouse, though IL-7Ralpha+ cells are found to scatter over the intestine [21].

Analytical, diagnostic and therapeutic context of Il7r


  1. Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R{alpha} mutant mice. Osborne, L.C., Dhanji, S., Snow, J.W., Priatel, J.J., Ma, M.C., Miners, M.J., Teh, H.S., Goldsmith, M.A., Abraham, N. J. Exp. Med. (2007) [Pubmed]
  2. Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development. Laouar, Y., Crispe, I.N., Flavell, R.A. Blood (2004) [Pubmed]
  3. EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15. Sauce, D., Larsen, M., Curnow, S.J., Leese, A.M., Moss, P.A., Hislop, A.D., Salmon, M., Rickinson, A.B. Blood (2006) [Pubmed]
  4. Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients. Giliani, S., Mori, L., de Saint Basile, G., Le Deist, F., Rodriguez-Perez, C., Forino, C., Mazzolari, E., Dupuis, S., Elhasid, R., Kessel, A., Galambrun, C., Gil, J., Fischer, A., Etzioni, A., Notarangelo, L.D. Immunol. Rev. (2005) [Pubmed]
  5. Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiation. Welniak, L.A., Khaled, A.R., Anver, M.R., Komschlies, K.L., Wiltrout, R.H., Durum, S., Ruscetti, F.R., Blazar, B.R., Murphy, W.J. J. Immunol. (2001) [Pubmed]
  6. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., Weissman, I.L. Cell (1997) [Pubmed]
  7. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Corcoran, A.E., Riddell, A., Krooshoop, D., Venkitaraman, A.R. Nature (1998) [Pubmed]
  8. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Khaled, A.R., Li, W.Q., Huang, J., Fry, T.J., Khaled, A.S., Mackall, C.L., Muegge, K., Young, H.A., Durum, S.K. Immunity (2002) [Pubmed]
  9. Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development. Boesteanu, A., Silva, A.D., Nakajima, H., Leonard, W.J., Peschon, J.J., Joyce, S. J. Exp. Med. (1997) [Pubmed]
  10. Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. Sitnicka, E., Brakebusch, C., Martensson, I.L., Svensson, M., Agace, W.W., Sigvardsson, M., Buza-Vidas, N., Bryder, D., Cilio, C.M., Ahlenius, H., Maraskovsky, E., Peschon, J.J., Jacobsen, S.E. J. Exp. Med. (2003) [Pubmed]
  11. Interleukin 7 receptor-deficient mice lack gammadelta T cells. Maki, K., Sunaga, S., Komagata, Y., Kodaira, Y., Mabuchi, A., Karasuyama, H., Yokomuro, K., Miyazaki, J.I., Ikuta, K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  12. Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. Munitic, I., Williams, J.A., Yang, Y., Dong, B., Lucas, P.J., El Kassar, N., Gress, R.E., Ashwell, J.D. Blood (2004) [Pubmed]
  13. A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice. Crompton, T., Outram, S.V., Buckland, J., Owen, M.J. Eur. J. Immunol. (1997) [Pubmed]
  14. IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches. Yoshida, H., Honda, K., Shinkura, R., Adachi, S., Nishikawa, S., Maki, K., Ikuta, K., Nishikawa, S.I. Int. Immunol. (1999) [Pubmed]
  15. Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. Durum, S.K., Candèias, S., Nakajima, H., Leonard, W.J., Baird, A.M., Berg, L.J., Muegge, K. J. Exp. Med. (1998) [Pubmed]
  16. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. Di Santo, J.P., Aifantis, I., Rosmaraki, E., Garcia, C., Feinberg, J., Fehling, H.J., Fischer, A., von Boehmer, H., Rocha, B. J. Exp. Med. (1999) [Pubmed]
  17. Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. Levin, S.D., Koelling, R.M., Friend, S.L., Isaksen, D.E., Ziegler, S.F., Perlmutter, R.M., Farr, A.G. J. Immunol. (1999) [Pubmed]
  18. PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. DeKoter, R.P., Lee, H.J., Singh, H. Immunity (2002) [Pubmed]
  19. CD8+ T cell contraction is controlled by early inflammation. Badovinac, V.P., Porter, B.B., Harty, J.T. Nat. Immunol. (2004) [Pubmed]
  20. Two distinct pathways of positive selection for thymocytes. Akashi, K., Kondo, M., Weissman, I.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  21. Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage. Adachi, S., Yoshida, H., Honda, K., Maki, K., Saijo, K., Ikuta, K., Saito, T., Nishikawa, S.I. Int. Immunol. (1998) [Pubmed]
  22. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. Luther, S.A., Ansel, K.M., Cyster, J.G. J. Exp. Med. (2003) [Pubmed]
  23. Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3. Paxian, S., Merkle, H., Riemann, M., Wilda, M., Adler, G., Hameister, H., Liptay, S., Pfeffer, K., Schmid, R.M. Gastroenterology (2002) [Pubmed]
  24. Kappa-opioid regulation of thymocyte IL-7 receptor and C-C chemokine receptor 2 expression. Zhang, L., Rogers, T.J. J. Immunol. (2000) [Pubmed]
  25. Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Kunisawa, J., Takahashi, I., Okudaira, A., Hiroi, T., Katayama, K., Ariyama, T., Tsutsumi, Y., Nakagawa, S., Kiyono, H., Mayumi, T. Eur. J. Immunol. (2002) [Pubmed]
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