The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Hist3  -  histone cluster 3

Mus musculus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hist3


High impact information on Hist3


Biological context of Hist3


Anatomical context of Hist3

  • We introduced modified mouse histone H3 genes into mouse fibroblasts and studied the regulation of several different H3 mRNAs that are not terminated with a normal histone 3' end [12].
  • However, transcripts containing the same sequences including the snRNA 3' end followed by the histone 3' end were present in the cytoplasm on polyribosomes [13].

Associations of Hist3 with chemical compounds


Regulatory relationships of Hist3


Other interactions of Hist3

  • G9a, which was coimmunoprecipitated with hepatic SHP, methylated Lys-9 of histone 3 (H3K9) in vitro [17].
  • Although accumulating evidence suggests that methylation of histone 3, lysine 36 (H3K36) is associated with actively transcribed genes, we show that the SET domain of Smyd2 mediates H3K36 dimethylation and that Smyd2 represses transcription from an SV40-luciferase reporter [18].
  • These results show that the histone 3' end processing signals can function independently of the histone promoter and the transcripts which are normally polyadenylated (alpha globin) can be stabilized by a poly(A)- histone mRNA 3' terminus [19].

Analytical, diagnostic and therapeutic context of Hist3

  • A Ca(2+)-calmodulin dependent histone 3 kinase was partially purified from a low salt (150 mM NaCl) nuclear extract of mouse leukemia cells by calmodulin-Sepharose affinity chromatography [10].


  1. Mitotic cell cycle proteins increase in podocytes despite lack of proliferation. Petermann, A.T., Pippin, J., Hiromura, K., Monkawa, T., Durvasula, R., Couser, W.G., Kopp, J., Shankland, S.J. Kidney Int. (2003) [Pubmed]
  2. B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Johnson, K., Pflugh, D.L., Yu, D., Hesslein, D.G., Lin, K.I., Bothwell, A.L., Thomas-Tikhonenko, A., Schatz, D.G., Calame, K. Nat. Immunol. (2004) [Pubmed]
  3. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Gonzalo, S., Jaco, I., Fraga, M.F., Chen, T., Li, E., Esteller, M., Blasco, M.A. Nat. Cell Biol. (2006) [Pubmed]
  4. Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. Yan, Q., Huang, J., Fan, T., Zhu, H., Muegge, K. EMBO J. (2003) [Pubmed]
  5. Mutual induction of growth factor gene expression by epidermal-dermal cell interaction. Smola, H., Thiekötter, G., Fusenig, N.E. J. Cell Biol. (1993) [Pubmed]
  6. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Chen, Y.X., Yan, J., Keeshan, K., Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S., Hua, X. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. The human and mouse replication-dependent histone genes. Marzluff, W.F., Gongidi, P., Woods, K.R., Jin, J., Maltais, L.J. Genomics (2002) [Pubmed]
  8. An intact histone 3'-processing site is required for transcription termination in a mouse histone H2a gene. Chodchoy, N., Pandey, N.B., Marzluff, W.F. Mol. Cell. Biol. (1991) [Pubmed]
  9. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. Glauben, R., Batra, A., Fedke, I., Zeitz, M., Lehr, H.A., Leoni, F., Mascagni, P., Fantuzzi, G., Dinarello, C.A., Siegmund, B. J. Immunol. (2006) [Pubmed]
  10. Ca(2+)-calmodulin-dependent phosphorylation of arginine in histone 3 by a nuclear kinase from mouse leukemia cells. Wakim, B.T., Aswad, G.D. J. Biol. Chem. (1994) [Pubmed]
  11. EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells. Koyanagi, M., Baguet, A., Martens, J., Margueron, R., Jenuwein, T., Bix, M. J. Biol. Chem. (2005) [Pubmed]
  12. Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3' end of the mRNA. Levine, B.J., Chodchoy, N., Marzluff, W.F., Skoultchi, A.I. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  13. The histone mRNA 3' end is required for localization of histone mRNA to polyribosomes. Sun, J., Pilch, D.R., Marzluff, W.F. Nucleic Acids Res. (1992) [Pubmed]
  14. Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. Kawamura, T., Ono, K., Morimoto, T., Wada, H., Hirai, M., Hidaka, K., Morisaki, T., Heike, T., Nakahata, T., Kita, T., Hasegawa, K. J. Biol. Chem. (2005) [Pubmed]
  15. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Tremolizzo, L., Doueiri, M.S., Dong, E., Grayson, D.R., Davis, J., Pinna, G., Tueting, P., Rodriguez-Menendez, V., Costa, E., Guidotti, A. Biol. Psychiatry (2005) [Pubmed]
  16. Differential expression of calcium-activated chloride channels (CLCA) gene family members in the small intestine of cystic fibrosis mouse models. Leverkoehne, I., Holle, H., Anton, F., Gruber, A.D. Histochem. Cell Biol. (2006) [Pubmed]
  17. Coordinated Recruitment of Histone Methyltransferase G9a and Other Chromatin-Modifying Enzymes in SHP-Mediated Regulation of Hepatic Bile Acid Metabolism. Fang, S., Miao, J., Xiang, L., Ponugoti, B., Treuter, E., Kemper, J.K. Mol. Cell. Biol. (2007) [Pubmed]
  18. Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Brown, M.A., Sims, R.J., Gottlieb, P.D., Tucker, P.W. Mol. Cancer (2006) [Pubmed]
  19. Globin gene transcripts can utilize histone gene 3' end processing signals. Whitelaw, E., Coates, A., Proudfoot, N.J. Nucleic Acids Res. (1986) [Pubmed]
WikiGenes - Universities