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Gene Review

Igh-8  -  immunoglobulin heavy chain 8 (heavy chain...

Mus musculus

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High impact information on Igh-8

  • Furthermore, nucleotide sequence comparisons reveal that the region encompassing the site of germline Igh-8 transcription initiation is highly homologous to part of the Ig2b exon, and is also conserved upstream of the Igh-1 switch region [1].
  • In splenic B cell cultures treated with lipopolysaccharide (LPS), germline Igh-8 transcript levels are upregulated after 8 h due to increased transcription [1].
  • Furthermore, they were identical in deduced amino acid sequences to those from non-autoimmune BALB/c mice, indicating no allelic difference of Igh-8 between these two strains [2].


  1. Structure and expression of mouse germline immunoglobulin gamma 3 heavy chain transcripts induced by the mitogen lipopolysaccharide. Gerondakis, S., Gaff, C., Goodman, D.J., Grumont, R.J. Immunogenetics (1991) [Pubmed]
  2. Cloning and cDNA sequence analysis of nephritogenic monoclonal antibodies derived from an MRL/lpr lupus mouse. Takahashi, S., Itoh, J., Nose, M., Ono, M., Yamamoto, T., Kyogoku, M. Mol. Immunol. (1993) [Pubmed]
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