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MeSH Review

Mice, Inbred BALB C

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Disease relevance of Mice, Inbred BALB C


Psychiatry related information on Mice, Inbred BALB C


High impact information on Mice, Inbred BALB C

  • Study of the genetically susceptible BALB/c mouse has shown failure to downmodulate IL-4 production in response to infection, a response that is critically associated with the failure to develop appropriate Th1 responses [10].
  • The continuously proliferating clones L/B AgA2, CB/Bm 7, Ba/C1, and Bc/Bm 11 were established from bone marrow of MRL/LPR, CBA/J, and BALB/c mice [11].
  • The immune response to phosphorylcholine in BALB/c mice has been well characterized [12].
  • Here we show that T. gondii uracil auxotrophs are completely avirulent not only in immune-competent BALB/c mice but also in mice that lack interferon-gamma [4].
  • A colon carcinoma cell line from BALB/c mice, CT26, was stably transfected with a vector encoding mouse CD95L and was inoculated into C57BL/6 mice [13].

Chemical compound and disease context of Mice, Inbred BALB C

  • The effects of doxorubicin (DOX) and DOX entrapped in standardized liposomes [mean diameter, 0.15 micron; (DOX-Lip)] on the survival of mice bearing liver metastases of mouse colon carcinoma CT38LD (C57BL/6J mice) or CT26 (BALB/c mice) were investigated [14].
  • The growth of mammary adenocarcinomas in BALB/c mice fed a diet containing 10% corn oil (CO), which has about 60% of its fatty acids as linoleate, was significantly greater than that for tumors in mice fed diets containing either 10% hydrogenated cottonseed oil (HCTO), which has no linoleate, or 10% CO plus 0.003% indomethacin (IM) [15].
  • In previous studies we demonstrated that administration of buthionine sulfoximine (BSO) to athymic BALB/c mice bearing intracranial human glioma xenografts resulted in highly selective depletion of glutathione in neoplastic tissue with minimal effects on contralateral normal brain tissue [16].
  • Development of resistance to MOPC-315 plasmacytoma after intralesional and intraperitoneal melphalan therapy of tumor-bearing BALB/c mice. I. Enhancement of in vivo rejection responses by combined chemotherapy-immunotherapy [17].
  • When ascites cells were inoculated sc into BALB/c mice receiving daily injections of 2 mg cortisol, tumors did not form [18].

Biological context of Mice, Inbred BALB C


Anatomical context of Mice, Inbred BALB C

  • These findings indicate that p53 alteration commonly occurs in spontaneously immortalized BALB/c mouse embryo fibroblasts passaged on a 3T3 schedule and, therefore, may be an important event for the immortalization process [24].
  • The induction of the CD4+ and CD8+ T cells producing the polarized patterns of cytokines was not restricted to BALB/c mice, as cells from Ox sensitized C57B1/6 and B10.D2 mice produced the same patterns [25].
  • Regulation of azophenylarsonate-specific repertoire expression. 1. Frequency of cross-reactive idiotype-positive B cells in A/J and BALB/c mice [26].
  • Moreover, PC-immune lymph node cells could passively transfer PC-specific DTH responses to naive BALB/c mice and it was possible to demonstrate that the cells responsible for such passively transferred responses were T lymphocytes [27].
  • Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse [28].

Associations of Mice, Inbred BALB C with chemical compounds


Gene context of Mice, Inbred BALB C

  • At 8 wk of infection, by which time lymphoid organs were repopulated with L3T4+ cells, GK1.5-pretreated BALB/c mice produced IFN-gamma, but not IL-4 message [33].
  • Neutralization of IL-4 in resistant BALB/c mice resulted in more severe arthritis whereas neutralization of IFN-gamma in susceptible C3H/HeJ mice attenuated the severity of disease [34].
  • Production of 40 pg/ml TNF-alpha by clone J2T12 consistently did not change the growth rate in vitro, but drastically suppressed tumor growth when injected into syngeneic BALB/c mice [35].
  • A single injection of 0.5-1 microgram of recombinant murine IL-10 reproducibly protected BALB/c mice from a lethal intraperitoneal injection of endotoxin [36].
  • Administration of HMG-1 to Balb/c mice significantly increased serum TNF levels in vivo [37].

Analytical, diagnostic and therapeutic context of Mice, Inbred BALB C


  1. Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse. Cohen, J.C., Shank, P.R., Morris, V.L., Cardiff, R., Varmus, H.E. Cell (1979) [Pubmed]
  2. BALB and Kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent balb/c mouse epidermal keratinocyte lines. Weissman, B.E., Aaronson, S.A. Cell (1983) [Pubmed]
  3. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Sambandamurthy, V.K., Wang, X., Chen, B., Russell, R.G., Derrick, S., Collins, F.M., Morris, S.L., Jacobs, W.R. Nat. Med. (2002) [Pubmed]
  4. De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Fox, B.A., Bzik, D.J. Nature (2002) [Pubmed]
  5. Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation. Slavin, S., Strober, S., Fuks, Z., Kaplan, H.S. Science (1976) [Pubmed]
  6. Induction of the immune response to Legionella pneumophila cytolysin by monoclonal anti-idiotypic antibodies. Spitsin, S.V., Drobyshevskaya, E.I., Barkhatova, O.I., Belyi, Y.F., Tartakovsky, I.S., Nesterenko, V.G. J. Immunol. (1991) [Pubmed]
  7. Influence of benzodiazepine tranquilizers on scopolamine-induced locomotor stimulation in mice. Sansone, M. Psychopharmacology (Berl.) (1980) [Pubmed]
  8. Reduction of regional brain glucose metabolism following different durations of chronic ethanol consumption in mice: a selective effect on diencephalic structures. Bontempi, B., Beracochea, D., Jaffard, R., Destrade, C. Neuroscience (1996) [Pubmed]
  9. Evaluation of the effects of alpha-phenyl-N-tert-butyl nitrone pretreatment on the neurobehavioral effects of methamphetamine. Kita, T., Matsunari, Y., Saraya, T., Shimada, K., O'Hara, K., Kubo, K., Wagner, G.C., Nakashima, T. Life Sci. (2000) [Pubmed]
  10. The regulation of immunity to Leishmania major. Reiner, S.L., Locksley, R.M. Annu. Rev. Immunol. (1995) [Pubmed]
  11. Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Palacios, R., Steinmetz, M. Cell (1985) [Pubmed]
  12. Antibody diversity: somatic hypermutation of rearranged VH genes. Kim, S., Davis, M., Sinn, E., Patten, P., Hood, L. Cell (1981) [Pubmed]
  13. Inhibition of the alloantibody response by CD95 ligand. Arai, H., Chan, S.Y., Bishop, D.K., Nabel, G.J. Nat. Med. (1997) [Pubmed]
  14. Effects of liposome-entrapped doxorubicin on liver metastases of mouse colon carcinomas 26 and 38. Mayhew, E.G., Goldrosen, M.H., Vaage, J., Rustum, Y.M. J. Natl. Cancer Inst. (1987) [Pubmed]
  15. Effect of dietary fat on growth kinetics of transplantable mammary adenocarcinoma in BALB/c mice. Gabor, H., Hillyard, L.A., Abraham, S. J. Natl. Cancer Inst. (1985) [Pubmed]
  16. Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. Friedman, H.S., Colvin, O.M., Griffith, O.W., Lippitz, B., Elion, G.B., Schold, S.C., Hilton, J., Bigner, D.D. J. Natl. Cancer Inst. (1989) [Pubmed]
  17. Development of resistance to MOPC-315 plasmacytoma after intralesional and intraperitoneal melphalan therapy of tumor-bearing BALB/c mice. I. Enhancement of in vivo rejection responses by combined chemotherapy-immunotherapy. Adler, A., Altbaum, I. J. Natl. Cancer Inst. (1982) [Pubmed]
  18. Nonmutational alteration in glucocorticoid sensitivity of lymphosarcoma P1798. Davis, J.M., Chan, A.K., Thompson, E.A. J. Natl. Cancer Inst. (1980) [Pubmed]
  19. Transcriptional activation of immunoglobulin alpha heavy-chain genes by translocation of the c-myc oncogene. Dean, M., Kent, R.B., Sonenshein, G.E. Nature (1983) [Pubmed]
  20. Two steroid 21-hydroxylase genes are located in the murine S region. White, P.C., Chaplin, D.D., Weis, J.H., Dupont, B., New, M.I., Seidman, J.G. Nature (1984) [Pubmed]
  21. Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5. Kozak, C.A., Rowe, W.P. Science (1979) [Pubmed]
  22. Late clonal selection and expansion of the TEPC-15 germ-line specificity. Fung, J., Köhler, H. J. Exp. Med. (1980) [Pubmed]
  23. MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells. Mandik-Nayak, L., Seo, S.J., Sokol, C., Potts, K.M., Bui, A., Erikson, J. J. Exp. Med. (1999) [Pubmed]
  24. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Harvey, D.M., Levine, A.J. Genes Dev. (1991) [Pubmed]
  25. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells. Xu, H., DiIulio, N.A., Fairchild, R.L. J. Exp. Med. (1996) [Pubmed]
  26. Regulation of azophenylarsonate-specific repertoire expression. 1. Frequency of cross-reactive idiotype-positive B cells in A/J and BALB/c mice. Sigal, N.H. J. Exp. Med. (1982) [Pubmed]
  27. Suppression of hapten-specific delayed-type hypersensitivity responses in mice by idiotype-specific suppressor T cells after administration of anti-idiotypic antibodies. Yamamoto, H., Nonaka, M., Katz, D.H. J. Exp. Med. (1979) [Pubmed]
  28. Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse. Fisher, D.A., Hunt, S.W., Hood, L. J. Exp. Med. (1985) [Pubmed]
  29. A new immunomodulating compound (AS-101) with potential therapeutic application. Sredni, B., Caspi, R.R., Klein, A., Kalechman, Y., Danziger, Y., Ben Ya'akov, M., Tamari, T., Shalit, F., Albeck, M. Nature (1987) [Pubmed]
  30. Deficiency of a kidney metalloproteinase activity in inbred mouse strains. Beynon, R.J., Bond, J.S. Science (1983) [Pubmed]
  31. Induction of anti-tobacco mosaic virus antibodies in mice by rabbit antiidiotypic antibodies. Francotte, M., Urbain, J. J. Exp. Med. (1984) [Pubmed]
  32. Genetic control of specific immune suppression. IV. Responsiveness to the random copolymer L-glutamic acid50-L-tyrosine50 induced in BALB/c mice by cyclophosphamide. Debré, P., Waltenbaugh, C., Dorf, M.E., Benacerraf, B. J. Exp. Med. (1976) [Pubmed]
  33. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. Heinzel, F.P., Sadick, M.D., Holaday, B.J., Coffman, R.L., Locksley, R.M. J. Exp. Med. (1989) [Pubmed]
  34. T helper phenotype and genetic susceptibility in experimental Lyme disease. Matyniak, J.E., Reiner, S.L. J. Exp. Med. (1995) [Pubmed]
  35. Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer. Blankenstein, T., Qin, Z.H., Uberla, K., Müller, W., Rosen, H., Volk, H.D., Diamantstein, T. J. Exp. Med. (1991) [Pubmed]
  36. Interleukin 10 protects mice from lethal endotoxemia. Howard, M., Muchamuel, T., Andrade, S., Menon, S. J. Exp. Med. (1993) [Pubmed]
  37. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. Andersson, U., Wang, H., Palmblad, K., Aveberger, A.C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., Tracey, K.J. J. Exp. Med. (2000) [Pubmed]
  38. GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. Baker-LePain, J.C., Sarzotti, M., Fields, T.A., Li, C.Y., Nicchitta, C.V. J. Exp. Med. (2002) [Pubmed]
  39. Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils. Chertov, O., Ueda, H., Xu, L.L., Tani, K., Murphy, W.J., Wang, J.M., Howard, O.M., Sayers, T.J., Oppenheim, J.J. J. Exp. Med. (1997) [Pubmed]
  40. Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases. Specht, J.M., Wang, G., Do, M.T., Lam, J.S., Royal, R.E., Reeves, M.E., Rosenberg, S.A., Hwu, P. J. Exp. Med. (1997) [Pubmed]
  41. Activation of intracisternal A particles in mouse liver by diethylnitrosamine. Shinozuka, H., Estes, L.W. J. Natl. Cancer Inst. (1977) [Pubmed]
  42. Separation on Percoll density gradients of cells derived from malignant ascites of mice. Hamburger, A.W., Dunn, F.E., Tencer, K.L. J. Natl. Cancer Inst. (1983) [Pubmed]
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