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Gene Review:

DEDD2 - death effector domain containing 2

Homo sapiens

Synonyms: DED-containing protein FLAME-3, DNA-binding death effector domain-containing protein 2, FADD-like anti-apoptotic molecule 3, FLAME-3, FLAME3, ...

Roth, W. et al., Lee, J.C. et al.

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High impact information on DEDD2

Early in apoptosis, both cytosolic DEDD and its close homologue DEDD2 formed filaments that colocalized with and depended on K8/18 and active caspase-3 [1].
DEDD2 interacts with FLIP, but not with Fas-associated death domain (FADD) or caspase-8 [2].
These findings suggest that DEDD2 is involved in the regulation of nuclear events mediated by the extrinsic apoptosis pathway [2].
In contrast, Bax- or staurosporine-mediated cell death is not affected by expression of DEDD2 [2].
Mutagenesis studies revealed that the translocation of the DED of DEDD2 to the nucleus is essential for its pro-apoptotic activity [2].

Anatomical context of DEDD2

DEDD2 mRNA is expressed widely in adult human tissues with highest levels in liver, kidney, and peripheral blood leukocytes [2].

Other interactions of DEDD2

Identification and characterization of DEDD2, a death effector domain-containing protein [2].

References

DEDD regulates degradation of intermediate filaments during apoptosis. Lee, J.C., Schickling, O., Stegh, A.H., Oshima, R.G., Dinsdale, D., Cohen, G.M., Peter, M.E. J. Cell Biol. (2002) [Pubmed]
Identification and characterization of DEDD2, a death effector domain-containing protein. Roth, W., Stenner-Liewen, F., Pawlowski, K., Godzik, A., Reed, J.C. J. Biol. Chem. (2002) [Pubmed]

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DEDD2	Bos taurus
DEDD2	Canis lupus familiaris
dedd1	Danio rerio
Dedd2	Mus musculus
Dedd2	Rattus norvegicus

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