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Gene Review:

jc - Jackson circler

Mus musculus

This record was replaced with 109205.

Calderon, A. et al., Alagramam, K.N. et al., Chaib, H. et al.

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High impact information on jc

Three deaf mouse mutants Jackson circler (jc), Waltzer (v) and Ames waltzer (av) have been localized to the homologous murine region on chromosome 10 [1].
In open-field behavior tests, homozygous jc mutants exhibited abnormal circling and ambulatory behavior that was indistinguishable from that of phenotypically similar mutants with defects in the vestibule of the inner ear [2].
The mutant locus was mapped to a region on mouse chromosome 10 close to three spontaneous recessive mutations causing deafness: Ames waltzer (av), Waltzer (v), and Jackson circler (jc) [3].

Biological context of jc

5. In a large intrasubspecific intercross, jc localized to a 0.2cM interval at position 25cM on chromosome 10, which is homologous to the human 6q21 region [2].

References

Mapping of DFNB12, a gene for a non-syndromal autosomal recessive deafness, to chromosome 10q21-22. Chaib, H., Place, C., Salem, N., Dodé, C., Chardenoux, S., Weissenbach, J., el Zir, E., Loiselet, J., Petit, C. Hum. Mol. Genet. (1996) [Pubmed]
Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Calderon, A., Derr, A., Stagner, B.B., Johnson, K.R., Martin, G., Noben-Trauth, K. Hear. Res. (2006) [Pubmed]
Neuroepithelial defects of the inner ear in a new allele of the mouse mutation Ames waltzer. Alagramam, K.N., Zahorsky-Reeves, J., Wright, C.G., Pawlowski, K.S., Erway, L.C., Stubbs, L., Woychik, R.P. Hear. Res. (2000) [Pubmed]

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