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Gene Review

Lamc2  -  laminin, gamma 2

Mus musculus

Synonyms: AA589349, Epiligrin subunit gamma, Kalinin subunit gamma, Kalinin/nicein/epiligrin 100 kDa subunit, Laminin B2t chain, ...
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High impact information on Lamc2

  • BACKGROUND: Laminin gamma2 (Lamc2), one of the polypeptides in laminin-332 (laminin-5), is prominent in the basement membrane of alveolar walls and airways of developing and adult lung [1].
  • Branching morphogenesis by lung bud culture was similar in Lamc2-/- and littermate control lungs [1].

Other interactions of Lamc2

  • To investigate the mechanism of two forms of messages (5.1 and 2.4 kb) in mouse Lamc2, a gene encoding for the gamma2 chain of epithelial cell-specific laminin 5, we analyzed approximately 40 kb of genomic DNA containing the sequences from the first intron to the 23rd exon to the 3' untranscribed region [2].

Analytical, diagnostic and therapeutic context of Lamc2

  • Immunofluorescence analysis associated the condition to the absent expression of the gamma2 chain of laminin 5 and designated Lamc2 as the candidate gene [3].
  • METHODS: Examination of lung development in Lamc2-/- mice through 1-2 days postnatal was accomplished by morphometric analysis, lung bud culture, electron microscopy, immunohistochemical and immunofluorescence staining [1].


  1. Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation. Nguyen, N.M., Pulkkinen, L., Schlueter, J.A., Meneguzzi, G., Uitto, J., Senior, R.M. Respir. Res. (2006) [Pubmed]
  2. Alternative transcriptional initiation and splicing of mouse Lamc2 message. Lee, G., Kim, M.G., Yim, J.B., Hong, S.H. Mol. Cells (2001) [Pubmed]
  3. Animal models for skin blistering conditions: absence of laminin 5 causes hereditary junctional mechanobullous disease in the Belgian horse. Spirito, F., Charlesworth, A., Linder, K., Ortonne, J.P., Baird, J., Meneguzzi, G. J. Invest. Dermatol. (2002) [Pubmed]
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