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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lx  -  luxate

Mus musculus

 
 
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High impact information on Lx

  • Misexpression of Hoxd-12 in other lateral plate derivatives (sternum, pelvis) likewise phenocopies several luxoid/luxate class mouse mutants that all share ectopic Shh signalling [1].
  • Thus, ectopic Shh is not a primary defect of the lx mutation [2].
  • We show here that the mouse mutation luxate (lx) exhibits dose-dependent reduction in the size of the Fgf8 expression domain in the ectoderm from the initial stage of limb development [2].
  • Rather, our results indicate that the lx mutation affects the positioning of the anteroposterior border in developing hindlimb buds [2].

References

  1. Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop. Knezevic, V., De Santo, R., Schughart, K., Huffstadt, U., Chiang, C., Mahon, K.A., Mackem, S. Development (1997) [Pubmed]
  2. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Yada, Y., Makino, S., Chigusa-Ishiwa, S., Shiroishi, T. Int. J. Dev. Biol. (2002) [Pubmed]
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