Gene Review:
Fgf8 - fibroblast growth factor 8
Mus musculus
Synonyms:
AIGF, Aigf, Androgen-induced growth factor, FGF-8, Fgf-8, ...
- Increased expression of fibroblast growth factor 8 in human breast cancer. Marsh, S.K., Bansal, G.S., Zammit, C., Barnard, R., Coope, R., Roberts-Clarke, D., Gomm, J.J., Coombes, R.C., Johnston, C.L. Oncogene (1999)
- Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected]. Suzuki, K., Bachiller, D., Chen, Y.P., Kamikawa, M., Ogi, H., Haraguchi, R., Ogino, Y., Minami, Y., Mishina, Y., Ahn, K., Crenshaw, E.B., Yamada, G. Development (2003)
- Preferential activation of Fgf8 by proviral insertion in mammary tumors of Wnt1 transgenic mice. Kapoun, A.M., Shackleford, G.M. Oncogene. (1997)
- MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia. Daphna-Iken, D., Shankar, D.B., Lawshé, A., Ornitz, D.M., Shackleford, G.M., MacArthur, C.A. Oncogene. (1998)
- Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Morgan, E.A., Nguyen, S.B., Scott, V., Stadler, H.S. Development (2003)
- Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Storm, E.E., Garel, S., Borello, U., Hebert, J.M., Martinez, S., McConnell, S.K., Martin, G.R., Rubenstein, J.L. Development (2006)
- Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Tanaka, A., Miyamoto, K., Minamino, N., Takeda, M., Sato, B., Matsuo, H., Matsumoto, K. Proc. Natl. Acad. Sci. U. S. A. (1992)
- Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation. Erdreich-Epstein, A., Ganguly, A.K., Shi, X.H., Zimonjic, D.B., Shackleford, G.M. Genes Chromosomes Cancer (2006)
- Activation of fibroblast growth factor 8 gene expression in human embryonal carcinoma cells. Wu, J., Payson, R.A., Lang, J.C., Chiu, I.M. J. Steroid Biochem. Mol. Biol. (1997)
- Fgf8 signalling from the AER is essential for normal limb development. Lewandoski, M., Sun, X., Martin, G.R. Nat. Genet. (2000)
- Fgf8 is required for outgrowth and patterning of the limbs. Moon, A.M., Capecchi, M.R. Nat. Genet. (2000)
- FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Ye, W., Shimamura, K., Rubenstein, J.L., Hynes, M.A., Rosenthal, A. Cell (1998)
- Regulation of osteoblast differentiation: a novel function for fibroblast growth factor 8. Valta, M.P., Hentunen, T., Qu, Q., Valve, E.M., Harjula, A., Seppänen, J.A., Väänänen, H.K., Härkönen, P.L. Endocrinology (2006)
- Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Sun, X., Meyers, E.N., Lewandoski, M., Martin, G.R. Genes Dev. (1999)
- Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis. Herzog, W., Sonntag, C., von der Hardt, S., Roehl, H.H., Varga, Z.M., Hammerschmidt, M. Development (2004)
- The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Chi, C.L., Martinez, S., Wurst, W., Martin, G.R. Development (2003)
- Development of the mammalian urethra is controlled by Fgfr2-IIIb. Petiot, A., Perriton, C.L., Dickson, C., Cohn, M.J. Development (2005)
- FGF8 initiates inner ear induction in chick and mouse. Ladher, R.K., Wright, T.J., Moon, A.M., Mansour, S.L., Schoenwolf, G.C. Genes Dev. (2005)
- Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Liu, Y., Liu, C., Yamada, Y., Fan, C.M. Development (2002)
- EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Liu, A., Joyner, A.L. Development (2001)
- A genetic link between Tbx1 and fibroblast growth factor signaling. Vitelli, F., Taddei, I., Morishima, M., Meyers, E.N., Lindsay, E.A., Baldini, A. Development (2002)
- Androgen-induced growth factor and its receptor: demonstration of the androgen-induced autocrine loop in mouse mammary carcinoma cells. Sato, B., Kouhara, H., Koga, M., Kasayama, S., Saito, H., Sumitani, S., Hashimoto, K., Kishimoto, T., Tanaka, A., Matsumoto, K. J. Steroid Biochem. Mol. Biol. (1993)
- Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005)
- Expression and characterization of fibroblast growth factor 8 from Mexican axolotl, Ambystoma mexicanum. Lee, S.Y., Kim, W.S., Yang, J.M. Mol. Cells (2000)
- FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. MacArthur, C.A., Lawshé, A., Xu, J., Santos-Ocampo, S., Heikinheimo, M., Chellaiah, A.T., Ornitz, D.M. Development (1995)
- Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea. Jacques, B.E., Montcouquiol, M.E., Layman, E.M., Lewandoski, M., Kelley, M.W. Development (2007)
- Pathogenesis of ectrodactyly in the Dactylaplasia mouse: aberrant cell death of the apical ectodermal ridge. Seto, M.L., Nunes, M.E., MacArthur, C.A., Cunningham, M.L. Teratology (1997)
- FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Liu, A., Losos, K., Joyner, A.L. Development (1999)
- Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Guo, C., Qiu, H.Y., Huang, Y., Chen, H., Yang, R.Q., Chen, S.D., Johnson, R.L., Chen, Z.F., Ding, Y.Q. Development (2007)
- FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development. Bei, M., Maas, R. Development (1998)
- Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Lee, S.M., Danielian, P.S., Fritzsch, B., McMahon, A.P. Development (1997)
- The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs. Lettice, L., Hecksher-Sørensen, J., Hill, R.E. Development (1999)
- Formation of Rathke's pouch requires dual induction from the diencephalon. Takuma, N., Sheng, H.Z., Furuta, Y., Ward, J.M., Sharma, K., Hogan, B.L., Pfaff, S.L., Westphal, H., Kimura, S., Mahon, K.A. Development (1998)
- Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Martinez-Barbera, J.P., Signore, M., Boyl, P.P., Puelles, E., Acampora, D., Gogoi, R., Schubert, F., Lumsden, A., Simeone, A. Development (2001)
- Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern. Grimm, C., Chatterjee, B., Favor, J., Immervoll, T., Löster, J., Klopp, N., Sandulache, R., Graw, J. Dev. Genet. (1998)
- Differentially expressed fibroblast growth factors regulate skeletal muscle development through autocrine and paracrine mechanisms. Hannon, K., Kudla, A.J., McAvoy, M.J., Clase, K.L., Olwin, B.B. J. Cell Biol. (1996)