High impact information on Grid2ip

• Although Delphilin specifically interacts with the GluRdelta2 C-terminus via its PDZ domain, the physiological role of the interaction is not yet understood [1].
• Delphilin is identified as a Glutamate receptor delta2 (GluRdelta2) subunit interacting protein, consisting of a PDZ domain and formin homology (FH) domains 1 and 2, in addition to a C-terminal coiled-coil structure [1].
• Here, we report that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons [1].
• Mouse Grid2ip links glutamate receptor delta2 subunit with actin cytoskeleton and various signaling molecules [2].
• Here, we identified and characterized human GRID2IP gene as well as rat Grid2ip gene by using bioinformatics [2].

Anatomical context of Grid2ip

• Both Delphilin alpha and beta localized at the dendritic spines with GluRdelta2; however, dendritic shafts in cultured Purkinje cells also included Delphilin beta [1].
• In situ hybridization demonstrated the highest expression of Delphilin mRNA in Purkinje cells [3].

Co-localisations of Grid2ip

• The post-embedding immunogold technique demonstrated that Delphilin is selectively localized at the postsynaptic junction site of the parallel fiber-Purkinje cell synapse and colocalized with GluRdelta2 [3].

Analytical, diagnostic and therapeutic context of Grid2ip

• Yeast two-hybrid and surface plasmon resonance (SPR) analyses indicated that Delphilin interacts with the GluRdelta2 C terminus via its PDZ domain [3].

References