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Gene Review

Grid2ip  -  glutamate receptor, ionotropic, delta 2...

Mus musculus

Synonyms: Delphilin, Glutamate receptor, ionotropic, delta 2-interacting protein 1, delphilin
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High impact information on Grid2ip

  • Although Delphilin specifically interacts with the GluRdelta2 C-terminus via its PDZ domain, the physiological role of the interaction is not yet understood [1].
  • Delphilin is identified as a Glutamate receptor delta2 (GluRdelta2) subunit interacting protein, consisting of a PDZ domain and formin homology (FH) domains 1 and 2, in addition to a C-terminal coiled-coil structure [1].
  • Here, we report that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons [1].
  • Mouse Grid2ip links glutamate receptor delta2 subunit with actin cytoskeleton and various signaling molecules [2].
  • Here, we identified and characterized human GRID2IP gene as well as rat Grid2ip gene by using bioinformatics [2].

Anatomical context of Grid2ip


Co-localisations of Grid2ip


Analytical, diagnostic and therapeutic context of Grid2ip


  1. Identification and characterization of a novel Delphilin variant with an alternative N-terminus. Yamashita, T., Miyagi, Y., Ono, M., Ito, H., Watanabe, K., Sonoda, T., Tsuzuki, K., Ozawa, S., Aoki, I., Okuda, K., Mishina, M., Kawamoto, S. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  2. Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
  3. Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. Miyagi, Y., Yamashita, T., Fukaya, M., Sonoda, T., Okuno, T., Yamada, K., Watanabe, M., Nagashima, Y., Aoki, I., Okuda, K., Mishina, M., Kawamoto, S. J. Neurosci. (2002) [Pubmed]
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