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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PDIA3P1  -  protein disulfide isomerase family A,...

Homo sapiens

Synonyms: ERp60, GRP58P, PDIA3P
 
 
 
 
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High impact information on PDIA3P

  • Chondrocytes produce 1alpha,25(OH)(2)D(3) (10(-8)M), which binds ERp60, activating PLA(2), and resulting lysophospholipids lead to MV membrane disorganization, releasing active MMPs [1].
  • Like plasma membranes (PM), MVs contain the 1alpha,25(OH)(2)D(3)-binding protein ERp60, phospholipase A(2) (PLA(2)), and caveolin-1, but appear to lack nuclear Vitamin D receptors (VDRs) [1].

References

  1. 1alpha,25(OH)(2)D(3) is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60 activated matrix vesicle metalloproteinases. Boyan, B.D., Wong, K.L., Fang, M., Schwartz, Z. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
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