Gene Review:
CAV1 - caveolin 1, caveolae protein, 22kDa
Homo sapiens
Synonyms:
BSCL3, CAV, CGL3, Caveolin-1, LCCNS, ...
Mehlhorn,
Schwinger,
Zhang,
Mader,
N. Cordes,
Zerial,
Popken,
Reed,
T.B. Brunner,
B. Sipos,
G. Klöppel,
Pelkmans,
W.G. McKenna,
Lindsley,
Cantor,
Helenius,
Butters,
E.J. Bernhard,
Kifor,
Gao,
Bloch,
Arnhold,
Lu,
C. Pilarsky,
Klinz,
Schneider,
Schinköthe,
S. Frick,
Bürli,
Buck,
Kifor,
Zheng,
Moore,
Brixius,
Oyama,
Addicks,
Richie,
Komers,
R. Grützmann,
Schutzer,
Brown,
Desai,
Anderson,
Schmidt,
Staib,
- Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Sunaga, N., Miyajima, K., Suzuki, M., Sato, M., White, M.A., Ramirez, R.D., Shay, J.W., Gazdar, A.F., Minna, J.D. Cancer Res. (2004)
- Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. Lee, H., Park, D.S., Razani, B., Russell, R.G., Pestell, R.G., Lisanti, M.P. Am. J. Pathol. (2002)
- Herpes zoster in patients with carcinoma of the lung. Feld, R., Evans, W.K., DeBoer, G. Am. J. Med. (1982)
- Identification of candidate genes involved in the reversal of malignant phenotype of osteosarcoma cells transfected with the liver/bone/kidney alkaline phosphatase gene. Zucchini, C., Bianchini, M., Valvassori, L., Perdichizzi, S., Benini, S., Manara, M.C., Solmi, R., Strippoli, P., Picci, P., Carinci, P., Scotlandi, K. Bone (2004)
- Caveolin-1 expression is associated with a basal-like phenotype in sporadic and hereditary breast cancer. Pinilla, S.M., Honrado, E., Hardisson, D., Benítez, J., Palacios, J. Breast Cancer Res. Treat. (2006)
- Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1. Cordes, N., Frick, S., Brunner, T.B., Pilarsky, C., Grützmann, R., Sipos, B., Klöppel, G., McKenna, W.G., Bernhard, E.J. Oncogene (2007)
- Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. Cantiani, L., Manara, M.C., Zucchini, C., De Sanctis, P., Zuntini, M., Valvassori, L., Serra, M., Olivero, M., Di Renzo, M.F., Colombo, M.P., Picci, P., Scotlandi, K. Cancer Res. (2007)
- Decreased trabecular smooth muscle and caveolin-1 expression in the penile tissue of aged rats. Bakircioglu, M.E., Sievert, K.D., Nunes, L., Lau, A., Lin, C.S., Lue, T.F. J. Urol. (2001)
- Concrete word dyslexia. Warrington, E.K. British journal of psychology (London, England : 1953) (1981)
- Role of caveolae and caveolins in health and disease. Cohen, A.W., Hnasko, R., Schubert, W., Lisanti, M.P. Physiol. Rev. (2004)
- Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Coyne, C.B., Bergelson, J.M. Cell (2006)
- Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Pelkmans, L., Bürli, T., Zerial, M., Helenius, A. Cell (2004)
- Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells. Nasu, Y., Timme, T.L., Yang, G., Bangma, C.H., Li, L., Ren, C., Park, S.H., DeLeon, M., Wang, J., Thompson, T.C. Nat. Med. (1998)
- Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis. Aldred, M.A., Ginn-Pease, M.E., Morrison, C.D., Popkie, A.P., Gimm, O., Hoang-Vu, C., Krause, U., Dralle, H., Jhiang, S.M., Plass, C., Eng, C. Cancer Res. (2003)
- Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. Engelman, J.A., Lee, R.J., Karnezis, A., Bearss, D.J., Webster, M., Siegel, P., Muller, W.J., Windle, J.J., Pestell, R.G., Lisanti, M.P. J. Biol. Chem. (1998)
- Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. Lu, M.L., Schneider, M.C., Zheng, Y., Zhang, X., Richie, J.P. J. Biol. Chem. (2001)
- Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. Bhatnagar, A., Sheffler, D.J., Kroeze, W.K., Compton-Toth, B., Roth, B.L. J. Biol. Chem. (2004)
- Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. Shajahan, A.N., Wang, A., Decker, M., Minshall, R.D., Liu, M.C., Clarke, R. J. Biol. Chem. (2007)
- Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays. Wikman, H., Seppänen, J.K., Sarhadi, V.K., Kettunen, E., Salmenkivi, K., Kuosma, E., Vainio-Siukola, K., Nagy, B., Karjalainen, A., Sioris, T., Salo, J., Hollmén, J., Knuutila, S., Anttila, S. J. Pathol. (2004)
- Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer. Sagara, Y., Mimori, K., Yoshinaga, K., Tanaka, F., Nishida, K., Ohno, S., Inoue, H., Mori, M. Br. J. Cancer (2004)
- Induction of alpha-caveolin-1 (alphaCAV1) expression in bovine granulosa cells in response to an ovulatory dose of human chorionic gonadotropin. Diouf, M.N., Lefebvre, R., Silversides, D.W., Sirois, J., Lussier, J.G. Mol. Reprod. Dev. (2006)
- Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Scherer, P.E., Okamoto, T., Chun, M., Nishimoto, I., Lodish, H.F., Lisanti, M.P. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. Fujimoto, T., Kogo, H., Ishiguro, K., Tauchi, K., Nomura, R. J. Cell Biol. (2001)
- Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering. Tang, W., Hemler, M.E. J. Biol. Chem. (2004)
- Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. Orlichenko, L., Huang, B., Krueger, E., McNiven, M.A. J. Biol. Chem. (2006)
- Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program. Matthews, L., Berry, A., Ohanian, V., Ohanian, J., Garside, H., Ray, D. Mol. Endocrinol. (2008)
- The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. Breuza, L., Corby, S., Arsanto, J.P., Delgrossi, M.H., Scheiffele, P., Le Bivic, A. J. Cell. Sci. (2002)
- Attenuation of EGF signaling in senescent cells by caveolin. Park, W.Y., Cho, K.A., Park, J.S., Kim, D.I., Park, S.C. Ann. N. Y. Acad. Sci. (2001)
- Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. Brazer, S.C., Singh, B.B., Liu, X., Swaim, W., Ambudkar, I.S. J. Biol. Chem. (2003)
- Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Schilling, K., Opitz, N., Wiesenthal, A., Oess, S., Tikkanen, R., Müller-Esterl, W., Icking, A. Mol. Biol. Cell (2006)
- Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase. Labrecque, L., Nyalendo, C., Langlois, S., Durocher, Y., Roghi, C., Murphy, G., Gingras, D., Béliveau, R. J. Biol. Chem. (2004)
- The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Sowa, G., Pypaert, M., Fulton, D., Sessa, W.C. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Li, L., Ren, C.H., Tahir, S.A., Ren, C., Thompson, T.C. Mol. Cell. Biol. (2003)
- Phospho-eNOS Ser-114 in human mesenchymal stem cells: constitutive phosphorylation, nuclear localization and upregulation during mitosis. Klinz, F.J., Schmidt, A., Schinköthe, T., Arnhold, S., Desai, B., Popken, F., Brixius, K., Schwinger, R., Mehlhorn, U., Staib, P., Addicks, K., Bloch, W. Eur. J. Cell Biol. (2005)
- Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14). Lee, H., Woodman, S.E., Engelman, J.A., Volonté, D., Galbiati, F., Kaufman, H.L., Lublin, D.M., Lisanti, M.P. J. Biol. Chem. (2001)
- Expression of caveolin by bovine lymphocytes and antigen-presenting cells. Harris, J., Werling, D., Koss, M., Monaghan, P., Taylor, G., Howard, C.J. Immunology (2002)
- BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells. de Marco, M.C., Kremer, L., Albar, J.P., Martinez-Menarguez, J.A., Ballesta, J., Garcia-Lopez, M.A., Marazuela, M., Puertollano, R., Alonso, M.A. J. Biol. Chem. (2001)
- Decreased expression of caveolin-1 and altered regulation of mitogen-activated protein kinase in cultured bovine parathyroid cells and human parathyroid adenomas. Kifor, O., Kifor, I., Moore, F.D., Butters, R.R., Cantor, T., Gao, P., Brown, E.M. J. Clin. Endocrinol. Metab. (2003)
- Altered endothelial nitric oxide synthase targeting and conformation and caveolin-1 expression in the diabetic kidney. Komers, R., Schutzer, W.E., Reed, J.F., Lindsley, J.N., Oyama, T.T., Buck, D.C., Mader, S.L., Anderson, S. Diabetes (2006)
- Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. Liu, J., Razani, B., Tang, S., Terman, B.I., Ware, J.A., Lisanti, M.P. J. Biol. Chem. (1999)
- Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors. Feng, X., Gaeta, M.L., Madge, L.A., Yang, J.H., Bradley, J.R., Pober, J.S. J. Biol. Chem. (2001)
- CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1. Ohnuma, K., Yamochi, T., Uchiyama, M., Nishibashi, K., Yoshikawa, N., Shimizu, N., Iwata, S., Tanaka, H., Dang, N.H., Morimoto, C. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. Ruiz-Ballesteros, E., Mollejo, M., Rodriguez, A., Camacho, F.I., Algara, P., Martinez, N., Pollán, M., Sanchez-Aguilera, A., Menarguez, J., Campo, E., Martinez, P., Mateo, M., Piris, M.A. Blood (2005)
- Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. Couet, J., Sargiacomo, M., Lisanti, M.P. J. Biol. Chem. (1997)
- E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription. Torres, V.A., Tapia, J.C., Rodriguez, D.A., Lladser, A., Arredondo, C., Leyton, L., Quest, A.F. Mol. Cell. Biol. (2007)
- Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts. Liou, J.Y., Deng, W.G., Gilroy, D.W., Shyue, S.K., Wu, K.K. J. Biol. Chem. (2001)