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Gene Review

smg-2  -  Protein SMG-2

Caenorhabditis elegans

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High impact information on smg-2

  • Thirteen of the 122 gained introns are in genes whose protein products function in premRNA processing, including three gains in the gene for spliceosomal protein SF3B1 and two in the nonsense-mediated decay gene smg-2 [1].
  • We name these genes smg-1 through smg-6 (suppressor with morphogenetic effect on genitalia), in order to distinguish them from mab (male abnormal) genes that can mutate to produce abnormal genitalia but which do not act as suppressors (smg-1 and smg-2 are new names for two previously described genes, mab-1 and mab-11) [2].


  1. Origins of recently gained introns in Caenorhabditis. Coghlan, A., Wolfe, K.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. A new kind of informational suppression in the nematode Caenorhabditis elegans. Hodgkin, J., Papp, A., Pulak, R., Ambros, V., Anderson, P. Genetics (1989) [Pubmed]
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