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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Upf1  -  CG1559 gene product from transcript CG1559-RA

Drosophila melanogaster

Synonyms: CG1559, Dm-Upf1, DmUpf1, Dmel\CG1559, Regulator of nonsense transcripts 1 homolog, ...
 
 
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High impact information on Upf1

  • These include SMG5, SMG7, and UPF1, which function in nonsense-mediated mRNA decay (NMD), and the Argonaute proteins that are essential for RNA interference (RNAi) and the micro-RNA (miRNA) pathway [1].
  • Mapping and molecular analyses show that photoshop mutations are loss-of-function mutations in the Drosophila homologs of NMD genes Upf1, Upf2, and Smg1 [2].
  • Here we identify the Drosophila orthologue of one of these factors, Upf1, and document its expression during embryogenesis [3].
 

Biological context of Upf1

  • By contrast, we find that the PI3K-related kinase Smg1 potentiates but is not required for NMD or for viability, implying that the Upf1 phosphorylation cycle that is required for mammalian and Caenorhabditis elegans NMD has a more limited role during Drosophila development [2].
 

Other interactions of Upf1

  • Genetic mosaic analysis shows that Upf1 and Upf2 are required for growth and/or survival of imaginal cell clones, but this defect can be overcome if surrounding wild-type cells are eliminated [2].

References

  1. A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. Rehwinkel, J., Behm-Ansmant, I., Gatfield, D., Izaurralde, E. RNA (2005) [Pubmed]
  2. Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. Metzstein, M.M., Krasnow, M.A. PLoS Genet. (2006) [Pubmed]
  3. A Hox gene mutation that triggers nonsense-mediated RNA decay and affects alternative splicing during Drosophila development. Alonso, C.R., Akam, M. Nucleic Acids Res. (2003) [Pubmed]
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