Gene Review:
NAM7 - ATP-dependent RNA helicase NAM7
Saccharomyces cerevisiae S288c
Synonyms:
ATP-dependent helicase NAM7, IFS2, MOF4, Nonsense-mediated mRNA decay protein 1, Nuclear accommodation of mitochondria 7 protein, ...
- The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames. Ruiz-Echevarría, M.J., Peltz, S.W. Cell (2000)
- Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Cui, Y., Hagan, K.W., Zhang, S., Peltz, S.W. Genes Dev. (1995)
- Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. He, F., Jacobson, A. Genes Dev. (1995)
- Two adjacent nuclear genes, ISF1 and NAM7/UPF1, cooperatively participate in mitochondrial functions in Saccharomyces cerevisiae. Altamura, N., Dujardin, G., Groudinsky, O., Slonimski, P.P. Mol. Gen. Genet. (1994)
- Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs. He, F., Jacobson, A. Mol. Cell. Biol. (2001)
- Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway. Lew, J.E., Enomoto, S., Berman, J. Mol. Cell. Biol. (1998)
- Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p. Maderazo, A.B., He, F., Mangus, D.A., Jacobson, A. Mol. Cell. Biol. (2000)
- Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution. Maderazo, A.B., Belk, J.P., He, F., Jacobson, A. Mol. Cell. Biol. (2003)
- Overexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance. de Pinto, B., Lippolis, R., Castaldo, R., Altamura, N. Mol. Microbiol. (2004)
- An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA. Welch, E.M., Jacobson, A. EMBO J. (1999)
- A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells. Sun, X., Perlick, H.A., Dietz, H.C., Maquat, L.E. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing. Bond, A.T., Mangus, D.A., He, F., Jacobson, A. Mol. Cell. Biol. (2001)
- Role of RNA surveillance proteins Upf1/CpaR, Upf2 and Upf3 in the translational regulation of yeast CPA1 gene. Messenguy, F., Vierendeels, F., Piérard, A., Delbecq, P. Curr. Genet. (2002)
- Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. Cui, Y., Dinman, J.D., Peltz, S.W. EMBO J. (1996)
- Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover. Weng, Y., Czaplinski, K., Peltz, S.W. Mol. Cell. Biol. (1996)
- An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation. Mitchell, P., Tollervey, D. Mol. Cell (2003)
- Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. He, F., Brown, A.H., Jacobson, A. Mol. Cell. Biol. (1997)
- The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay. González, C.I., Ruiz-Echevarría, M.J., Vasudevan, S., Henry, M.F., Peltz, S.W. Mol. Cell (2000)
- Upf1p, a highly conserved protein required for nonsense-mediated mRNA decay, interacts with the nuclear pore proteins Nup100p and Nup116p. Nazarenus, T., Cedarberg, R., Bell, R., Cheatle, J., Forch, A., Haifley, A., Hou, A., Wanja Kebaara, B., Shields, C., Stoysich, K., Taylor, R., Atkin, A.L. Gene (2005)
- Transcript selection and the recruitment of mRNA decay factors for NMD in Saccharomyces cerevisiae. Culbertson, M.R., Neeno-Eckwall, E. RNA (2005)
- The Upf-dependent decay of wild-type PPR1 mRNA depends on its 5'-UTR and first 92 ORF nucleotides. Kebaara, B., Nazarenus, T., Taylor, R., Forch, A., Atkin, A.L. Nucleic Acids Res. (2003)
- NAM7 nuclear gene encodes a novel member of a family of helicases with a Zn-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae. Altamura, N., Groudinsky, O., Dujardin, G., Slonimski, P.P. J. Mol. Biol. (1992)
- The transcription of NAM7/UPF1 is enhanced in the absence of Cyp1p/Hap1p concomitant with the appearance of an ISF1-NAM7 cotranscript in Saccharomyces cerevisiae. Altamura, N., de Pinto, B., Castaldo, R., Verdiére, J. FEBS Lett. (1997)
- mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae. Dahlseid, J.N., Lew-Smith, J., Lelivelt, M.J., Enomoto, S., Ford, A., Desruisseaux, M., McClellan, M., Lue, N., Culbertson, M.R., Berman, J. Eukaryotic Cell (2003)
- Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA. Ruiz-Echevarría, M.J., González, C.I., Peltz, S.W. EMBO J. (1998)
- Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover. Hagan, K.W., Ruiz-Echevarria, M.J., Quan, Y., Peltz, S.W. Mol. Cell. Biol. (1995)
- The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Leeds, P., Peltz, S.W., Jacobson, A., Culbertson, M.R. Genes Dev. (1991)
- Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover. Zuk, D., Belk, J.P., Jacobson, A. Genetics (1999)
- Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites. Paulsen, M., Lund, C., Akram, Z., Winther, J.R., Horn, N., Møller, L.B. Am. J. Hum. Genet. (2006)