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Gene Review

smg-1  -  Protein SMG-1

Caenorhabditis elegans

 
 
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High impact information on kinase

  • In smg-1, smg-3, and smg-4 mutants, phosphorylation of SMG-2 was not detected [1].
  • Previous screens for smg mutations have likely not identified all genes involved in NMD, but efforts to identify additional smg genes are limited by the fact that almost 90% of smg mutations identified in genome-wide screens are alleles of smg-1, smg-2, or smg-5 [2].
  • We describe a modified screen for smg mutations that precludes isolating alleles of smg-1, smg-2, and smg-5 [2].
  • Eukaryotic mRNAs that contain premature stop codons are degraded more rapidly than their wild-type counterparts, a phenomenon termed "nonsense-mediated mRNA decay" (NMD) or "mRNA surveillance." Functions of six previously described Caenorhabditis elegans genes, smg-1 through smg-6, are required for NMD [2].
 

Anatomical context of kinase

  • We name these genes smg-1 through smg-6 (suppressor with morphogenetic effect on genitalia), in order to distinguish them from mab (male abnormal) genes that can mutate to produce abnormal genitalia but which do not act as suppressors (smg-1 and smg-2 are new names for two previously described genes, mab-1 and mab-11) [3].

References

  1. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Page, M.F., Carr, B., Anders, K.R., Grimson, A., Anderson, P. Mol. Cell. Biol. (1999) [Pubmed]
  2. smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Cali, B.M., Kuchma, S.L., Latham, J., Anderson, P. Genetics (1999) [Pubmed]
  3. A new kind of informational suppression in the nematode Caenorhabditis elegans. Hodgkin, J., Papp, A., Pulak, R., Ambros, V., Anderson, P. Genetics (1989) [Pubmed]
 
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