High impact information on sop-3

• Thus, sop-3 contributes to the combinatorial control of egl-5 by blocking egl-5 activation by MAB-5 and the Wnt pathway in inappropriate lineage branches [1].
• We describe the properties of a new gene, sop-3, that is required for the regulated expression of a C. elegans Hox gene, egl-5, in a postembryonic neuroectodermal cell lineage [1].
• The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression [1].
• The genetic properties of sop-3 are very similar to those of sop-1, which encodes a component of the transcriptional Mediator complex, and mutations in the two genes are synthetic lethal [1].

Biological context of sop-3

• Regulated expression of egl-5 in this cell lineage is necessary for development of the sensory rays of the male tail. sop-3 encodes a predicted novel protein of 1475 amino acids without clear homologs in other organisms [1].

Other interactions of sop-3

• In a sop-3 loss-of-function background, egl-5 is expressed ectopically in lineage branches that normally do not express this gene [1].

References