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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Lineage

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Disease relevance of Cell Lineage


High impact information on Cell Lineage

  • The failure of carriers of XLA, XSCID, and WAS to show signs of their gene defects can be explained by the preferential use of the normal, nonmutant X as the active X in the cell lineages affected by the gene defects [6].
  • These results elucidate how a single transcription factor, PU.1, through the cell context-specific activity of a key cis-regulatory element, affects the development of multiple cell lineages and can induce cancer [7].
  • Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage [8].
  • We propose that Hunchback and Krüppel control early-born temporal identity in neuroblast cell lineages [9].
  • Receptor tyrosine kinases often have critical roles in particular cell lineages by initiating signalling cascades in those lineages [10].

Chemical compound and disease context of Cell Lineage


Biological context of Cell Lineage


Anatomical context of Cell Lineage


Associations of Cell Lineage with chemical compounds

  • Conversion of 10T1/2 cells by 5-azacytidine provides a model for studying regulatory genes involved in cell lineage determination [26].
  • Establishment of the steroid-producing Leydig cell lineage is an event downstream of Sry that is critical for masculinization of mammalian embryos [27].
  • We show that beta forms of Neu differentiation factor (NDF), homologous to acetylcholine receptor-inducing activity, glial growth factor, and heregulin, prevent apoptotic death and stimulate DNA synthesis of the E14 Schwann cell precursor, an early cell in the rat Schwann cell lineage [28].
  • The Ly-5 system of the mouse is expressed exclusively by hematopoietic cells and comprises a series of glycoprotein isoforms that typify different hematopoietic cell lineages [29].
  • Sca-1 (stem cell antigen-1) enriches for murine prostate cells capable of regenerating tubular structures containing basal and luminal cell lineages in a dissociated cell prostate regeneration system [30].

Gene context of Cell Lineage

  • The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors [31].
  • Our findings further define the locus heterogeneity of Waardenburg-Hirschsprung syndromes, and point to an essential role of SOX10 in the development of two neural crest-derived human cell lineages [32].
  • Second, mab-3 activity is required for expression of the male V ray cell lineage [33].
  • These findings indicate that interaction of EDN3 with the endothelin-B receptor is essential in the development of neural crest-derived cell lineages [34].
  • Specification of pituitary cell lineages by the LIM homeobox gene Lhx3 [35].

Analytical, diagnostic and therapeutic context of Cell Lineage


  1. Clonally related cortical cells show several migration patterns. Walsh, C., Cepko, C.L. Science (1988) [Pubmed]
  2. Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Takayama, H., La Rochelle, W.J., Anver, M., Bockman, D.E., Merlino, G. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Heterogeneous PIG-A mutations in different cell lineages in paroxysmal nocturnal hemoglobinuria. Ostendorf, T., Nischan, C., Schubert, J., Grussenmeyer, T., Scholz, C., Zielinska-Skowronek, M., Schmidt, R.E. Blood (1995) [Pubmed]
  4. Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Carayon, P., Portier, M., Dussossoy, D., Bord, A., Petitprêtre, G., Canat, X., Le Fur, G., Casellas, P. Blood (1996) [Pubmed]
  5. Expression of vimentin intermediate filament cytoskeleton in acute nonlymphoblastic leukemias. Dellagi, K., Tabilio, A., Portier, M.M., Vainchenker, W., Castaigne, S., Guichard, J., Breton-Gorius, J., Brouet, J.C. Blood (1985) [Pubmed]
  6. Molecular approaches to analysis of X-linked immunodeficiencies. Conley, M.E. Annu. Rev. Immunol. (1992) [Pubmed]
  7. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Rosenbauer, F., Owens, B.M., Yu, L., Tumang, J.R., Steidl, U., Kutok, J.L., Clayton, L.K., Wagner, K., Scheller, M., Iwasaki, H., Liu, C., Hackanson, B., Akashi, K., Leutz, A., Rothstein, T.L., Plass, C., Tenen, D.G. Nat. Genet. (2006) [Pubmed]
  8. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., De Marchis, M.L., Nervi, C., Bozzoni, I. Cell (2005) [Pubmed]
  9. Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Isshiki, T., Pearson, B., Holbrook, S., Doe, C.Q. Cell (2001) [Pubmed]
  10. Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. DeChiara, T.M., Kimble, R.B., Poueymirou, W.T., Rojas, J., Masiakowski, P., Valenzuela, D.M., Yancopoulos, G.D. Nat. Genet. (2000) [Pubmed]
  11. Hyperplastic polyps: a cell lineage which both synthesizes and secretes trefoil-peptides and has phenotypic similarity with the ulcer-associated cell lineage. Hanby, A.M., Poulsom, R., Singh, S., Jankowski, J., Hopwood, D., Elia, G., Rogers, L., Patel, K., Wright, N.A. Am. J. Pathol. (1993) [Pubmed]
  12. Erythropoietic reconstitution, macrophages and reticulin fibrosis in bone marrow specimens of CML patients following allogeneic transplantation. Thiele, J., Kvasnicka, H.M., Beelen, D.W., Pilgram, B., Rose, A., Leder, L.D., Schaefer, U.W. Leukemia (2000) [Pubmed]
  13. Identification of a novel zinc finger gene, zf5-3, as a potential mediator of neuroblastoma differentiation. Dimitroulakos, J., Pienkowska, M., Sun, P., Farooq, S., Zielenska, M., Squire, J.A., Yeger, H. Int. J. Cancer (1999) [Pubmed]
  14. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Ogawa, M., Nomura, S., Car, B.D., Goldenring, J.R. Dig. Dis. Sci. (2006) [Pubmed]
  15. Rat model of the human "Triton" tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker. Nikitin AYu, n.u.l.l., Lennartz, K., Pozharisski, K.M., Rajewsky, M.F. Differentiation (1991) [Pubmed]
  16. Extra-embryonic function of Rb is essential for embryonic development and viability. Wu, L., de Bruin, A., Saavedra, H.I., Starovic, M., Trimboli, A., Yang, Y., Opavska, J., Wilson, P., Thompson, J.C., Ostrowski, M.C., Rosol, T.J., Woollett, L.A., Weinstein, M., Cross, J.C., Robinson, M.L., Leone, G. Nature (2003) [Pubmed]
  17. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Wright, N.A., Pike, C., Elia, G. Nature (1990) [Pubmed]
  18. The homeobox gene Distal-less induces ventral appendage development in Drosophila. Gorfinkiel, N., Morata, G., Guerrero, I. Genes Dev. (1997) [Pubmed]
  19. Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Baumeister, R., Liu, Y., Ruvkun, G. Genes Dev. (1996) [Pubmed]
  20. bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation. Motoyama, N., Kimura, T., Takahashi, T., Watanabe, T., Nakano, T. J. Exp. Med. (1999) [Pubmed]
  21. Widespread expression of the testis-determining gene SRY in a marsupial. Harry, J.L., Koopman, P., Brennan, F.E., Graves, J.A., Renfree, M.B. Nat. Genet. (1995) [Pubmed]
  22. Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Hall, D.H., Hedgecock, E.M. Cell (1991) [Pubmed]
  23. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Ellis, T., Gambardella, L., Horcher, M., Tschanz, S., Capol, J., Bertram, P., Jochum, W., Barrandon, Y., Busslinger, M. Genes Dev. (2001) [Pubmed]
  24. The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Lewis, B.C., Klimstra, D.S., Varmus, H.E. Genes Dev. (2003) [Pubmed]
  25. Foxp3 and natural regulatory T cells: key to a cell lineage? Ramsdell, F. Immunity (2003) [Pubmed]
  26. 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Konieczny, S.F., Emerson, C.P. Cell (1984) [Pubmed]
  27. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Yao, H.H., Whoriskey, W., Capel, B. Genes Dev. (2002) [Pubmed]
  28. Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Dong, Z., Brennan, A., Liu, N., Yarden, Y., Lefkowitz, G., Mirsky, R., Jessen, K.R. Neuron (1995) [Pubmed]
  29. Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA. Saga, Y., Tung, J.S., Shen, F.W., Boyse, E.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  30. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Xin, L., Lawson, D.A., Witte, O.N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Finney, M., Ruvkun, G., Horvitz, H.R. Cell (1988) [Pubmed]
  32. SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Pingault, V., Bondurand, N., Kuhlbrodt, K., Goerich, D.E., Préhu, M.O., Puliti, A., Herbarth, B., Hermans-Borgmeyer, I., Legius, E., Matthijs, G., Amiel, J., Lyonnet, S., Ceccherini, I., Romeo, G., Smith, J.C., Read, A.P., Wegner, M., Goossens, M. Nat. Genet. (1998) [Pubmed]
  33. mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans. Shen, M.M., Hodgkin, J. Cell (1988) [Pubmed]
  34. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Baynash, A.G., Hosoda, K., Giaid, A., Richardson, J.A., Emoto, N., Hammer, R.E., Yanagisawa, M. Cell (1994) [Pubmed]
  35. Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Sheng, H.Z., Zhadanov, A.B., Mosinger, B., Fujii, T., Bertuzzi, S., Grinberg, A., Lee, E.J., Huang, S.P., Mahon, K.A., Westphal, H. Science (1996) [Pubmed]
  36. Allele-specific in situ hybridization (ASISH) analysis: a novel technique which resolves differential allelic usage of H19 within the same cell lineage during human placental development. Adam, G.I., Cui, H., Miller, S.J., Flam, F., Ohlsson, R. Development (1996) [Pubmed]
  37. Mouse hepatitis virus 3 pathogenicity expressed by a lytic viral infection in bone marrow 14.8+ mu+ B lymphocyte subpopulations. Jolicoeur, P., Lamontagne, L. J. Immunol. (1989) [Pubmed]
  38. Identification of potent mixed leukocyte reaction-stimulatory cells in human bone marrow. Putative differentiation stage of human blood dendritic cells. Egner, W., McKenzie, J.L., Smith, S.M., Beard, M.E., Hart, D.N. J. Immunol. (1993) [Pubmed]
  39. Neuronal clones in the cerebral cortex show morphological and neurotransmitter heterogeneity during development. Lavdas, A.A., Mione, M.C., Parnavelas, J.G. Cereb. Cortex (1996) [Pubmed]
  40. Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies. Ise, T., Maeda, H., Santora, K., Xiang, L., Kreitman, R.J., Pastan, I., Nagata, S. Clin. Cancer Res. (2005) [Pubmed]
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