Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

hus-1 - Protein HUS-1

Caenorhabditis elegans

Harris, J. et al., Hofmann, E.R. et al., Gravel, C. et al.

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High impact information on hus-1

RESULTS: We demonstrate here that the Caenorhabditis elegans gene hus-1 is required for DNA damage-induced cell cycle arrest and apoptosis [1].
The C. elegans DNA damage response mutants mrt-2, hus-1, and clk-2(mn159) displayed 8- to 15-fold increases in the frequency of spontaneous mutation in their germlines [2].
We also show DNA damage increases expression of pme-5, a response that requires the DNA damage checkpoint gene hus-1 [3].

References

Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Hofmann, E.R., Milstein, S., Boulton, S.J., Ye, M., Hofmann, J.J., Stergiou, L., Gartner, A., Vidal, M., Hengartner, M.O. Curr. Biol. (2002) [Pubmed]
Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants. Harris, J., Lowden, M., Clejan, I., Tzoneva, M., Thomas, J.H., Hodgkin, J., Ahmed, S. Genetics (2006) [Pubmed]
The C. elegans gene pme-5: molecular cloning and role in the DNA-damage response of a tankyrase orthologue. Gravel, C., Stergiou, L., Gagnon, S.N., Desnoyers, S. DNA Repair (Amst.) (2004) [Pubmed]

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AgaP_AGAP011361	Anopheles gambiae str. PEST
HUS1	Canis lupus familiaris
zgc:162895	Danio rerio
Hus1-like	Drosophila melanogaster
HUS1	Gallus gallus
HUS1	Homo sapiens
HUS1	Macaca mulatta
MGG_12138	Magnaporthe oryzae 70-15
Hus1	Mus musculus
NCU11262	Neurospora crassa OR74A
HUS1	Pan troglodytes
Hus1	Rattus norvegicus
hus1	Schizosaccharomyces pombe 972h-
hus1	Xenopus (Silurana) tropicalis

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