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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

hus1  -  checkpoint clamp complex protein Hus1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on hus1

  • The hus1+ gene is one of six fission yeast genes, termed the checkpoint rad genes, which are essential for both the S-M and DNA damage checkpoints [1].
  • Although there is no gene related to hus1+ in the Saccharomyces cerevisiae genome, we have identified closely related mouse and human genes, suggesting that aspects of the checkpoint control mechanism are conserved between fission yeast and higher eukaryotes [1].
  • Phytochrome-induced expression of lig1, a homologue of the fission yeast cell-cycle checkpoint gene hus1, is associated with the developmental switch in Physarum polycephalum plasmodia [2].

References

  1. Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. Kostrub, C.F., Knudsen, K., Subramani, S., Enoch, T. EMBO J. (1998) [Pubmed]
  2. Phytochrome-induced expression of lig1, a homologue of the fission yeast cell-cycle checkpoint gene hus1, is associated with the developmental switch in Physarum polycephalum plasmodia. Kroneder, R., Cashmore, A.R., Marwan, W. Curr. Genet. (1999) [Pubmed]
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