Gene Review:
HUS1 - HUS1 checkpoint homolog (S. pombe)
Homo sapiens
Synonyms:
Checkpoint protein HUS1, hHUS1
- Fhit modulates the DNA damage checkpoint response. Ishii, H., Mimori, K., Inoue, H., Inageta, T., Ishikawa, K., Semba, S., Druck, T., Trapasso, F., Tani, K., Vecchione, A., Croce, C.M., Mori, M., Huebner, K. Cancer Res. (2006)
- Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. Yoshida, K., Wang, H.G., Miki, Y., Kufe, D. EMBO J. (2003)
- Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication. Taricani, L., Wang, T.S. Mol. Biol. Cell (2006)
- Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex. Francia, S., Weiss, R.S., Hande, M.P., Freire, R., d'Adda di Fagagna, F. Curr. Biol. (2006)
- A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex. Hirai, I., Wang, H.G. J. Biol. Chem. (2002)
- Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. Hang, H., Lieberman, H.B. Genomics (2000)
- Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. Hang, H., Zhang, Y., Dunbrack, R.L., Wang, C., Lieberman, H.B. Genomics (2002)
- The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. Friedrich-Heineken, E., Toueille, M., Tännler, B., Bürki, C., Ferrari, E., Hottiger, M.O., Hübscher, U. J. Mol. Biol. (2005)
- Determination of the genotype of a panel of human tumor cell lines for the human homologues of yeast cell cycle checkpoint control genes: identification of cell lines carrying homoallelic missense base substitutions. Ejima, Y., Yang, L. Somat. Cell Mol. Genet. (1999)
- Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Hofmann, E.R., Milstein, S., Boulton, S.J., Ye, M., Hofmann, J.J., Stergiou, L., Gartner, A., Vidal, M., Hengartner, M.O. Curr. Biol. (2002)
- Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin. Kinzel, B., Hall, J., Natt, F., Weiler, J., Cohen, D. Cancer (2002)
- Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene. Dufault, V.M., Oestreich, A.J., Vroman, B.T., Karnitz, L.M. Genomics (2003)
- Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. Wu, X., Shell, S.M., Zou, Y. Oncogene (2005)
- Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block. Dahm, K., Hübscher, U. Oncogene (2002)
- The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. St Onge, R.P., Udell, C.M., Casselman, R., Davey, S. Mol. Biol. Cell (1999)
- HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. Cai, R.L., Yan-Neale, Y., Cueto, M.A., Xu, H., Cohen, D. J. Biol. Chem. (2000)
- PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition. Komatsu, K., Wharton, W., Hang, H., Wu, C., Singh, S., Lieberman, H.B., Pledger, W.J., Wang, H.G. Oncogene (2000)
- Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. Jiang, K., Pereira, E., Maxfield, M., Russell, B., Goudelock, D.M., Sanchez, Y. J. Biol. Chem. (2003)
- Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex. Burtelow, M.A., Roos-Mattjus, P.M., Rauen, M., Babendure, J.R., Karnitz, L.M. J. Biol. Chem. (2001)