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Gene Review

cpn-3  -  Protein CPN-3

Caenorhabditis elegans

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Disease relevance of calponin


High impact information on calponin

  • Sequence analysis of a corresponding cDNA clone predicts a 357-amino acid, 40-kD protein that is similar to portions of the vertebrate smooth muscle proteins calponin and SM22 alpha, the Drosophila muscle protein mp20, the deduced product of the C. elegans cDNA cm7g3, and the rat neuronal protein np25 [2].
  • The molecular domain structure of the protein reveals similarity to the C-terminal repeat region of the smooth muscle actin-binding protein calponin [3].
  • Isolation and sequence of a tropomyosin-binding fragment of turkey gizzard calponin [4].


  1. Identification and characterization of an Onchocerca volvulus cDNA clone encoding a highly immunogenic calponin-like protein. Irvine, M., Huima, T., Prince, A.M., Lustigman, S. Mol. Biochem. Parasitol. (1994) [Pubmed]
  2. The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein. Goetinck, S., Waterston, R.H. J. Cell Biol. (1994) [Pubmed]
  3. UNC-87 is an actin-bundling protein. Kranewitter, W.J., Ylanne, J., Gimona, M. J. Biol. Chem. (2001) [Pubmed]
  4. Isolation and sequence of a tropomyosin-binding fragment of turkey gizzard calponin. Vancompernolle, K., Gimona, M., Herzog, M., Van Damme, J., Vandekerckhove, J., Small, V. FEBS Lett. (1990) [Pubmed]
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