The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

flnb-1  -  FiLamiN (actin binding protein) Beta

Caenorhabditis elegans

This record was discontinued.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of actin-binding


High impact information on actin-binding


Biological context of actin-binding


Anatomical context of actin-binding


Associations of actin-binding with chemical compounds


Physical interactions of actin-binding

  • The results indicate that C. elegans actin shares common biochemical properties with rabbit muscle actin, while actin-binding proteins can interact with C. elegans actin in a distinct manner from rabbit muscle actin [13].

Other interactions of actin-binding

  • The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins [14].
  • TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats [15].
  • In these highly conserved genes, two previously known gene families have been brought together, families encoding the actin-binding proteins related to gelsolin and the leucine-rich-repeat (LRR) group of proteins involved in protein-protein interactions [7].
  • The purified actin was highly pure and free of several known actin-binding proteins [13].


  1. The role of calponin in the gene profile of metastatic cells: inhibition of metastatic cell motility by multiple calponin repeats. Lener, T., Burgstaller, G., Gimona, M. FEBS Lett. (2004) [Pubmed]
  2. The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Varkey, J.P., Muhlrad, P.J., Minniti, A.N., Do, B., Ward, S. Genes Dev. (1995) [Pubmed]
  3. UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle. Ono, S., Baillie, D.L., Benian, G.M. J. Cell Biol. (1999) [Pubmed]
  4. Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo. Aroian, R.V., Field, C., Pruliere, G., Kenyon, C., Alberts, B.M. EMBO J. (1997) [Pubmed]
  5. A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant. Kreitmeier, M., Gerisch, G., Heizer, C., Müller-Taubenberger, A. J. Cell Biol. (1995) [Pubmed]
  6. The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans. Yang, Y., Lundquist, E.A. Mol. Cell. Biol. (2005) [Pubmed]
  7. The novel flightless-I gene brings together two gene families, actin-binding proteins related to gelsolin and leucine-rich-repeat proteins involved in Ras signal transduction. Claudianos, C., Campbell, H.D. Mol. Biol. Evol. (1995) [Pubmed]
  8. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Kawano, Y., Yoshimura, T., Tsuboi, D., Kawabata, S., Kaneko-Kawano, T., Shirataki, H., Takenawa, T., Kaibuchi, K. Mol. Cell. Biol. (2005) [Pubmed]
  9. UNC-87 is an actin-bundling protein. Kranewitter, W.J., Ylanne, J., Gimona, M. J. Biol. Chem. (2001) [Pubmed]
  10. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. Hemmings, L., Rees, D.J., Ohanian, V., Bolton, S.J., Gilmore, A.P., Patel, B., Priddle, H., Trevithick, J.E., Hynes, R.O., Critchley, D.R. J. Cell. Sci. (1996) [Pubmed]
  11. The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. Yu, J., Starr, D.A., Wu, X., Parkhurst, S.M., Zhuang, Y., Xu, T., Xu, R., Han, M. Dev. Biol. (2006) [Pubmed]
  12. Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner. Polet, D., Lambrechts, A., Ono, K., Mah, A., Peelman, F., Vandekerckhove, J., Baillie, D.L., Ampe, C., Ono, S. Cell Motil. Cytoskeleton (2006) [Pubmed]
  13. Purification and biochemical characterization of actin from Caenorhabditis elegans: its difference from rabbit muscle actin in the interaction with nematode ADF/cofilin. Ono, S. Cell Motil. Cytoskeleton (1999) [Pubmed]
  14. The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins. McKim, K.S., Matheson, C., Marra, M.A., Wakarchuk, M.F., Baillie, D.L. Mol. Gen. Genet. (1994) [Pubmed]
  15. TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats. Van Troys, M., Ono, K., Dewitte, D., Jonckheere, V., De Ruyck, N., Vandekerckhove, J., Ono, S., Ampe, C. Mol. Biol. Cell (2004) [Pubmed]
WikiGenes - Universities