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Gene Review

flnb-1  -  FiLamiN (actin binding protein) Beta

Caenorhabditis elegans

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Disease relevance of actin-binding

 

High impact information on actin-binding

 

Biological context of actin-binding

 

Anatomical context of actin-binding

 

Associations of actin-binding with chemical compounds

 

Physical interactions of actin-binding

  • The results indicate that C. elegans actin shares common biochemical properties with rabbit muscle actin, while actin-binding proteins can interact with C. elegans actin in a distinct manner from rabbit muscle actin [13].
 

Other interactions of actin-binding

  • The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins [14].
  • TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats [15].
  • In these highly conserved genes, two previously known gene families have been brought together, families encoding the actin-binding proteins related to gelsolin and the leucine-rich-repeat (LRR) group of proteins involved in protein-protein interactions [7].
  • The purified actin was highly pure and free of several known actin-binding proteins [13].

References

  1. The role of calponin in the gene profile of metastatic cells: inhibition of metastatic cell motility by multiple calponin repeats. Lener, T., Burgstaller, G., Gimona, M. FEBS Lett. (2004) [Pubmed]
  2. The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Varkey, J.P., Muhlrad, P.J., Minniti, A.N., Do, B., Ward, S. Genes Dev. (1995) [Pubmed]
  3. UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle. Ono, S., Baillie, D.L., Benian, G.M. J. Cell Biol. (1999) [Pubmed]
  4. Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo. Aroian, R.V., Field, C., Pruliere, G., Kenyon, C., Alberts, B.M. EMBO J. (1997) [Pubmed]
  5. A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant. Kreitmeier, M., Gerisch, G., Heizer, C., Müller-Taubenberger, A. J. Cell Biol. (1995) [Pubmed]
  6. The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans. Yang, Y., Lundquist, E.A. Mol. Cell. Biol. (2005) [Pubmed]
  7. The novel flightless-I gene brings together two gene families, actin-binding proteins related to gelsolin and leucine-rich-repeat proteins involved in Ras signal transduction. Claudianos, C., Campbell, H.D. Mol. Biol. Evol. (1995) [Pubmed]
  8. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Kawano, Y., Yoshimura, T., Tsuboi, D., Kawabata, S., Kaneko-Kawano, T., Shirataki, H., Takenawa, T., Kaibuchi, K. Mol. Cell. Biol. (2005) [Pubmed]
  9. UNC-87 is an actin-bundling protein. Kranewitter, W.J., Ylanne, J., Gimona, M. J. Biol. Chem. (2001) [Pubmed]
  10. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. Hemmings, L., Rees, D.J., Ohanian, V., Bolton, S.J., Gilmore, A.P., Patel, B., Priddle, H., Trevithick, J.E., Hynes, R.O., Critchley, D.R. J. Cell. Sci. (1996) [Pubmed]
  11. The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. Yu, J., Starr, D.A., Wu, X., Parkhurst, S.M., Zhuang, Y., Xu, T., Xu, R., Han, M. Dev. Biol. (2006) [Pubmed]
  12. Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner. Polet, D., Lambrechts, A., Ono, K., Mah, A., Peelman, F., Vandekerckhove, J., Baillie, D.L., Ampe, C., Ono, S. Cell Motil. Cytoskeleton (2006) [Pubmed]
  13. Purification and biochemical characterization of actin from Caenorhabditis elegans: its difference from rabbit muscle actin in the interaction with nematode ADF/cofilin. Ono, S. Cell Motil. Cytoskeleton (1999) [Pubmed]
  14. The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins. McKim, K.S., Matheson, C., Marra, M.A., Wakarchuk, M.F., Baillie, D.L. Mol. Gen. Genet. (1994) [Pubmed]
  15. TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats. Van Troys, M., Ono, K., Dewitte, D., Jonckheere, V., De Ruyck, N., Vandekerckhove, J., Ono, S., Ampe, C. Mol. Biol. Cell (2004) [Pubmed]
 
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