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Disease relevance of Onchocerca


High impact information on Onchocerca


Chemical compound and disease context of Onchocerca


Biological context of Onchocerca


Anatomical context of Onchocerca


Associations of Onchocerca with chemical compounds

  • A hydrophobic leader sequence of 32 amino acids was found, indicating a possible extracellular function of the onchocerca cysteine proteinase inhibitor [12].
  • The present study deals with the discovery and partial characterization of specific binding proteins for retinol and retinoic acid from filarial parasites (worms of the superfamily Filarioidea), including those from two species of Onchocerca [24].
  • This sequence is highly conserved when compared to calreticulin (a luminal ER protein), an Onchocerca surface antigen, and yeast and plant calnexin homologues [25].
  • Excretory-secretory products (ES) of adult male Onchocerca gibsoni contain phosphorylcholine (PC) [26].
  • Experimental describe the use of ethanediol to store Onchocerca microfilariae in liquid nitrogen [27].

Gene context of Onchocerca

  • Before treatment, Onchocerca volvulus antigen (OvA) elicited interleukin (IL)-5 production but inhibited production of IL-10, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-alpha [28].
  • Regulatory effects of Th1-type (IFN-gamma, IL-12) and Th2-type cytokines (IL-10, IL-13) on parasite-specific cellular responsiveness in Onchocerca volvulus-infected humans and exposed endemic controls [29].
  • Regulatory effects of IL-12 and IL-18 on Onchocerca volvulus- and Entamoeba histolytica-specific cellular reactivity and cytokine profiles [30].
  • A novel S100 ca2+-binding protein, termed calgranulin-related protein (CGRP), was purified to homogeneity from extracts of adult Onchocerca volvulus, a human tissue-dwelling parasite [31].
  • cDNAs from Onchocerca sp. encoding members of the MRS3/MRS4 class of mitochondrial solute carriers [32].

Analytical, diagnostic and therapeutic context of Onchocerca


  1. Characterization of an immunodominant Onchocerca volvulus antigen with patient sera and a monoclonal antibody. Lucius, R., Schulz-Key, H., Büttner, D.W., Kern, A., Kaltmann, B., Prod'hon, J., Seeber, F., Walter, R.D., Saxena, K.C., Diesfeld, H.J. J. Exp. Med. (1988) [Pubmed]
  2. Polymerase chain reaction-based diagnosis of Onchocerca volvulus infection: improved detection of patients with onchocerciasis. Zimmerman, P.A., Guderian, R.H., Aruajo, E., Elson, L., Phadke, P., Kubofcik, J., Nutman, T.B. J. Infect. Dis. (1994) [Pubmed]
  3. IL-4 and IL-13 regulation of ICAM-1 expression and eosinophil recruitment in Onchocerca volvulus keratitis. Berger, R.B., Blackwell, N.M., Lass, J.H., Diaconu, E., Pearlman, E. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  4. Characterization of enzymatically active Onchocerca volvulus Cu/Zn superoxide dismutase expressed in Escherichia coli. Henkle-Dührsen, K., Warnecke, C., Brattig, N., Liebau, E., Walter, R.D. Mol. Biochem. Parasitol. (1994) [Pubmed]
  5. Immunodiagnosis of Strongyloides stercoralis infection: a method for increasing the specificity of the indirect ELISA. Conway, D.J., Atkins, N.S., Lillywhite, J.E., Bailey, J.W., Robinson, R.D., Lindo, J.F., Bundy, D.A., Bianco, A.E. Trans. R. Soc. Trop. Med. Hyg. (1993) [Pubmed]
  6. Serological cross-reactivity between a human Ro/SS-A autoantigen (calreticulin) and the lambda Ral-1 antigen of Onchocerca volvulus. Lux, F.A., McCauliffe, D.P., Büttner, D.W., Lucius, R., Capra, J.D., Sontheimer, R.D., Lieu, T.S. J. Clin. Invest. (1992) [Pubmed]
  7. Biosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharides. Cipollo, J.F., Awad, A., Costello, C.E., Robbins, P.W., Hirschberg, C.B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Characterization of a novel filarial serine protease inhibitor, Ov-SPI-1, from Onchocerca volvulus, with potential multifunctional roles during development of the parasite. Ford, L., Guiliano, D.B., Oksov, Y., Debnath, A.K., Liu, J., Williams, S.A., Blaxter, M.L., Lustigman, S. J. Biol. Chem. (2005) [Pubmed]
  9. A novel cyclophilin from parasitic and free-living nematodes with a unique substrate- and drug-binding domain. Ma, D., Nelson, L.S., LeCoz, K., Poole, C., Carlow, C.K. J. Biol. Chem. (2002) [Pubmed]
  10. CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). Hall, L.R., Diaconu, E., Patel, R., Pearlman, E. J. Immunol. (2001) [Pubmed]
  11. The Ov20 protein of the parasitic nematode Onchocerca volvulus. A structurally novel class of small helix-rich retinol-binding proteins. Kennedy, M.W., Garside, L.H., Goodrick, L.E., McDermott, L., Brass, A., Price, N.C., Kelly, S.M., Cooper, A., Bradley, J.E. J. Biol. Chem. (1997) [Pubmed]
  12. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. Lustigman, S., Brotman, B., Huima, T., Prince, A.M., McKerrow, J.H. J. Biol. Chem. (1992) [Pubmed]
  13. A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation. Hall, L.R., Diaconu, E., Pearlman, E. J. Immunol. (2001) [Pubmed]
  14. Clinical pharmacokinetics of anthelmintic drugs. Edwards, G., Breckenridge, A.M. Clinical pharmacokinetics. (1988) [Pubmed]
  15. A novel type of glutathione S-transferase in Onchocerca volvulus. Liebau, E., Wildenburg, G., Walter, R.D., Henkle-Dührsen, K. Infect. Immun. (1994) [Pubmed]
  16. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae. Lustigman, S., McKerrow, J.H., Shah, K., Lui, J., Huima, T., Hough, M., Brotman, B. J. Biol. Chem. (1996) [Pubmed]
  17. Aggregation of equine platelets by Onchocerca cervicalis collagen. McConnell, L.A., Leid, R.W. Am. J. Pathol. (1983) [Pubmed]
  18. Molecular cloning and expression of SmIrV1, a Schistosoma mansoni antigen with similarity to calnexin, calreticulin, and OvRal1. Hawn, T.R., Tom, T.D., Strand, M. J. Biol. Chem. (1993) [Pubmed]
  19. Functional analysis of the glutathione S-transferase 3 from Onchocerca volvulus (Ov-GST-3): a parasite GST confers increased resistance to oxidative stress in Caenorhabditis elegans. Kampkötter, A., Volkmann, T.E., de Castro, S.H., Leiers, B., Klotz, L.O., Johnson, T.E., Link, C.D., Henkle-Dührsen, K. J. Mol. Biol. (2003) [Pubmed]
  20. Structural analysis and antibody response to the extracellular glutathione S-transferases from Onchocerca volvulus. Sommer, A., Nimtz, M., Conradt, H.S., Brattig, N., Boettcher, K., Fischer, P., Walter, R.D., Liebau, E. Infect. Immun. (2001) [Pubmed]
  21. Production of both IFN-gamma and IL-5 by Onchocerca volvulus S1 antigen-specific CD4+ T cells from putatively immune individuals. Doetze, A., Erttmann, K.D., Gallin, M.Y., Fleischer, B., Hoerauf, A. Int. Immunol. (1997) [Pubmed]
  22. Susceptibility of Brugia malayi and Onchocerca lienalis microfilariae to nitric oxide and hydrogen peroxide in cell-free culture and from IFN gamma-activated macrophages. Taylor, M.J., Cross, H.F., Mohammed, A.A., Trees, A.J., Bianco, A.E. Parasitology (1996) [Pubmed]
  23. Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria. Brattig, N.W., Büttner, D.W., Hoerauf, A. Microbes Infect. (2001) [Pubmed]
  24. Novel retinoid-binding proteins from filarial parasites. Sani, B.P., Vaid, A., Comley, J.C., Montgomery, J.A. Biochem. J. (1985) [Pubmed]
  25. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. Tjoelker, L.W., Seyfried, C.E., Eddy, R.L., Byers, M.G., Shows, T.B., Calderon, J., Schreiber, R.B., Gray, P.W. Biochemistry (1994) [Pubmed]
  26. Do excretory-secretory products of Onchocerca gibsoni contain phosphorylcholine attached to O-type glycans? MacDonald, M., Copeman, D.B., Harnett, W. Int. J. Parasitol. (1996) [Pubmed]
  27. An improved technique for the cryopreservation of Onchocerca microfilariae. Ham, P.J., Townson, S., James, E.R., Bianco, A.E. Parasitology (1981) [Pubmed]
  28. Transient changes in cytokine profiles following ivermectin treatment of onchocerciasis. Steel, C., Lujan-Trangay, A., Gonzalez-Peralta, C., Zea-Flores, G., Nutman, T.B. J. Infect. Dis. (1994) [Pubmed]
  29. Regulatory effects of Th1-type (IFN-gamma, IL-12) and Th2-type cytokines (IL-10, IL-13) on parasite-specific cellular responsiveness in Onchocerca volvulus-infected humans and exposed endemic controls. Soboslay, P.T., Lüder, C.G., Riesch, S., Geiger, S.M., Banla, M., Batchassi, E., Stadler, A., Schulz-Key, H. Immunology (1999) [Pubmed]
  30. Regulatory effects of IL-12 and IL-18 on Onchocerca volvulus- and Entamoeba histolytica-specific cellular reactivity and cytokine profiles. Pfaff, A.W., Kirch, A.K., Hoffmann, W.H., Banla, M., Schulz-Key, H., Geiger, S.M., Soboslay, P.T. Parasite Immunol. (2003) [Pubmed]
  31. Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. Marti, T., Erttmann, K.D., Gallin, M.Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  32. cDNAs from Onchocerca sp. encoding members of the MRS3/MRS4 class of mitochondrial solute carriers. Catmull, J., Miller, D.J. Biochim. Biophys. Acta (1996) [Pubmed]
  33. Prospective evaluation of enzyme-linked immunosorbent assay and immunoblot methods for the diagnosis of endemic Strongyloides stercoralis infection. Lindo, J.F., Conway, D.J., Atkins, N.S., Bianco, A.E., Robinson, R.D., Bundy, D.A. Am. J. Trop. Med. Hyg. (1994) [Pubmed]
  34. Crystallization of the major cytosolic glutathione S-transferase from Onchocerca volvulus. Höppner, J., Perbandt, M., Betzel, C.h., Walter, R.D., Liebau, E. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  35. A double-blind comparison of the efficacy and safety of ivermectin and diethylcarbamazine in a placebo controlled study of Senegalese patients with onchocerciasis. Diallo, S., Aziz, M.A., Lariviere, M., Diallo, J.S., Diop-Mar, I., N'Dir, O., Badiane, S., Py, D., Schulz-Key, H., Gaxotte, P. Trans. R. Soc. Trop. Med. Hyg. (1986) [Pubmed]
  36. Studies on glucose-6-phosphate dehydrogenase from the human parasite, Onchocerca volvulus. Titanji, V.P., Muluh, J.P., Tchoupe, J.R. Parasitol. Res. (1988) [Pubmed]
  37. An internal control for the detection of Onchocerca volvulus DNA by PCR-ELISA and rapid detection of specific PCR products by DNA Detection Test Strips. Pischke, S., Büttner, D.W., Liebau, E., Fischer, P. Trop. Med. Int. Health (2002) [Pubmed]
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