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Gene Review:

smg-5 - Protein SMG-5

Caenorhabditis elegans

Page, M.F. et al., Cali, B.M. et al.

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High impact information on smg-5

In smg-5, smg-6, and smg-7 mutants, a phosphorylated isoform of SMG-2 accumulated to abnormally high levels [1].
We describe a modified screen for smg mutations that precludes isolating alleles of smg-1, smg-2, and smg-5 [2].

Biological context of smg-5

In smg-2(r866) and smg-2(r895) mutants, which harbor single amino acid substitutions of the SMG-2 nucleotide binding site, phosphorylated SMG-2 accumulated to abnormally high levels, similar to those observed in smg-5, smg-6, and smg-7 mutants [1].

References

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Page, M.F., Carr, B., Anders, K.R., Grimson, A., Anderson, P. Mol. Cell. Biol. (1999) [Pubmed]
smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Cali, B.M., Kuchma, S.L., Latham, J., Anderson, P. Genetics (1999) [Pubmed]

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