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Gene Review:

oct-1 - Protein OCT-1

Caenorhabditis elegans

Wu, X. et al., George, R.L. et al.

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High impact information on transporter

It exhibits significant homology at the level of amino acid sequence to the C. elegans organic cation transporter and to the mammalian organic cation and anion transporters [1].
The substrate specificity of CeOCT1 is broad [2].
The location of this gene corresponds to the F52F12.1 gene locus on chromosome I. The predicted protein contains 12 putative transmembrane domains [2].
When expressed in mammalian cells, CeOCT1 induces the transport of the prototypical organic cation tetraethylammonium [2].
The oct1 gene is approximately 3.2 kb in size and consists of 12 exons [2].

References

Molecular cloning and functional characterization of a polyspecific organic anion transporter from Caenorhabditis elegans. George, R.L., Wu, X., Huang, W., Fei, Y.J., Leibach, F.H., Ganapathy, V. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter. Wu, X., Fei, Y.J., Huang, W., Chancy, C., Leibach, F.H., Ganapathy, V. Biochim. Biophys. Acta (1999) [Pubmed]

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AgaP_AGAP005530	Anopheles gambiae str. PEST
CG3790	Drosophila melanogaster

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