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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

aha-1  -  Protein AHA-1

Caenorhabditis elegans

 
 
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High impact information on aha-1

  • Both hif-1 and aha-1 are expressed in most cell types, and the gene products can be coimmunoprecipitated [1].
  • This function of ahr-1 requires aha-1, but not daf-21/hsp90 [2].
 

Biological context of aha-1

  • We show that dorsal migration of SDQR is mediated by UNC-6/Netrin, SAX-3/Robo, and UNC-129/TGFbeta, and this process requires the functions of both ahr-1 and its transcription factor dimerization partner aha-1 [3].
 

Anatomical context of aha-1

  • We report here that the C. elegans orthologs of AHR and ARNT, ahr-1 and aha-1, regulate GABAergic motor neuron fate specification [2].
 

Associations of aha-1 with chemical compounds

  • We show that ahr-1 and aha-1 promote cell-type-specific expression of soluble guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance [4].

References

  1. The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Jiang, H., Guo, R., Powell-Coffman, J.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans. Huang, X., Powell-Coffman, J.A., Jin, Y. Development (2004) [Pubmed]
  3. The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development. Qin, H., Powell-Coffman, J.A. Dev. Biol. (2004) [Pubmed]
  4. The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior. Qin, H., Zhai, Z., Powell-Coffman, J.A. Dev. Biol. (2006) [Pubmed]
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