The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

tgo  -  tango

Drosophila melanogaster

Synonyms: ARNT, Arnt, Aryl hydrocarbon receptor nuclear translocator homolog, CG11987, DARNT, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of tgo

  • Expression of DmagARNT in ARNT-lacking mouse Hepa-c4 cells resulted in the compensation for the loss of hypoxia response, suggesting the formation of a dimer with mouse HIF-1alpha and that the resulting heterodimer binds to the hypoxia-responsive elements (HRE), leading to transcription of the downstream luciferase gene [1].

High impact information on tgo

  • In its control of dendritic diversity among da neurons, ss likely acts independently of its known cofactor tango and through a regulatory program distinct from those involving cut and abrupt [2].
  • period and timeless tango: a dance of two clock genes [3].
  • PAS is an acronym formed from the names of the Drosophila period clock protein (PER), vertebrate aryl hydrocarbon receptor nuclear translocator (ARNT), and Drosophila single-minded protein (SIM) [4].
  • We show that both HIF-1 subunits are basic-helix-loop-helix proteins containing a PAS domain, defined by its presence in the Drosophila Per and Sim proteins and in the mammalian ARNT and AHR proteins [5].
  • The Dysfusion protein functions as a heterodimer with the Tango bHLH-PAS protein in vivo to form a putative DNA-binding complex [6].

Biological context of tgo

  • Lastly, expression of a C-terminal truncated tgo transgene specifically in the CNS midline and trachea resulted in reductions in the number of breathless-expressing cells [7].
  • Analysis of the transcriptional activation domain of the Drosophila tango bHLH-PAS transcription factor [7].
  • Drosophila tango is orthologous to mammalian Arnt and acts as a common dimerization partner for bHLH-PAS proteins during embryogenesis [7].
  • A transient transfection assay using Drosophila S2 tissue culture cells and wild-type and mutant Drosophila tango cDNAs was used to localize the activation domain of the Tango protein [7].
  • Expression of both single-minded and trachealess is highly restricted to their respective cell lineages, however tango is broadly expressed [8].

Anatomical context of tgo

  • In contrast, nuclear localization of Tango is developmentally regulated; it is localized to the cytoplasm in most cells except the CNS midline, salivary duct, and tracheal cells where it accumulates in nuclei [8].
  • Expression of D. magna ARNT was evident at the middle to late stages of embryonic development (about 25 h to 48 h after ovulation) in several tissues, including a pair of the 1st antenna, 2nd antenna, 2nd maxilla, five pairs of the thoracic limbs, the central nerve system, anus, dorsal organ, maxillary gland, and carapace [1].

Associations of tgo with chemical compounds

  • Dioxin and other aryl hydrocarbons bind to the PAS domain of Ahr, causing Ahr to translocate to the nucleus, where it dimerizes with another bHLH-PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt) [9].
  • The ta5 enhancer was comprised of a basal enhancer required for driving Bar expression and a negative regulatory motif serving as a binding site for the heterodimer of Spineless and Tango, homologs of the mammalian dioxin receptor and aryl hydrocarbon nuclear translocator, respectively [10].

Other interactions of tgo


Analytical, diagnostic and therapeutic context of tgo

  • Immunoprecipitation experiments with recombinant proteins indicate that mSIM-2 associates with the arnt gene product [13].


  1. Tissue-specific expression of a bHLH-PAS protein homologous to ARNT during the development of crustacean Daphnia magna. Tokishita, S., Kimura, S., Mandokora, Y., Kato, K., Shiga, Y., Takahashi, Y., Ohta, T., Yamagata, H. Gene (2006) [Pubmed]
  2. The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Kim, M.D., Jan, L.Y., Jan, Y.N. Genes Dev. (2006) [Pubmed]
  3. period and timeless tango: a dance of two clock genes. Reppert, S.M., Sauman, I. Neuron (1995) [Pubmed]
  4. Structure-function relationships of EcDOS, a heme-regulated phosphodiesterase from Escherichia coli. Sasakura, Y., Yoshimura-Suzuki, T., Kurokawa, H., Shimizu, T. Acc. Chem. Res. (2006) [Pubmed]
  5. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Wang, G.L., Jiang, B.H., Rue, E.A., Semenza, G.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. The Drosophila dysfusion basic helix-loop-helix (bHLH)-PAS gene controls tracheal fusion and levels of the trachealess bHLH-PAS protein. Jiang, L., Crews, S.T. Mol. Cell. Biol. (2003) [Pubmed]
  7. Analysis of the transcriptional activation domain of the Drosophila tango bHLH-PAS transcription factor. Sonnenfeld, M.J., Delvecchio, C., Sun, X. Dev. Genes Evol. (2005) [Pubmed]
  8. Regulation of bHLH-PAS protein subcellular localization during Drosophila embryogenesis. Ward, M.P., Mosher, J.T., Crews, S.T. Development (1998) [Pubmed]
  9. The spineless-aristapedia and tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. Emmons, R.B., Duncan, D., Estes, P.A., Kiefel, P., Mosher, J.T., Sonnenfeld, M., Ward, M.P., Duncan, I., Crews, S.T. Development (1999) [Pubmed]
  10. Temporal regulation of late expression of Bar homeobox genes during Drosophila leg development by Spineless, a homolog of the mammalian dioxin receptor. Kozu, S., Tajiri, R., Tsuji, T., Michiue, T., Saigo, K., Kojima, T. Dev. Biol. (2006) [Pubmed]
  11. Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Lavista-Llanos, S., Centanin, L., Irisarri, M., Russo, D.M., Gleadle, J.M., Bocca, S.N., Muzzopappa, M., Ratcliffe, P.J., Wappner, P. Mol. Cell. Biol. (2002) [Pubmed]
  12. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Frei, C., Edgar, B.A. Dev. Cell (2004) [Pubmed]
  13. The murine Sim-2 gene product inhibits transcription by active repression and functional interference. Moffett, P., Reece, M., Pelletier, J. Mol. Cell. Biol. (1997) [Pubmed]
WikiGenes - Universities