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Gene Review

ced-12  -  Protein CED-12

Caenorhabditis elegans

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High impact information on ced-12

  • In C. elegans, ced-12 is required for the engulfment of dying cells and for cell migration [1].
  • We provide evidence that ced-12 likely acts upstream of ced-10 during cell migration and phagocytosis and that CED-12 physically interacts with CED-5 and forms a ternary complex with CED-2 in vitro [2].
  • We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells [2].


  1. Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck. Yokoyama, N., deBakker, C.D., Zappacosta, F., Huddleston, M.J., Annan, R.S., Ravichandran, K.S., Miller, W.T. Biochemistry (2005) [Pubmed]
  2. C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Wu, Y.C., Tsai, M.C., Cheng, L.C., Chou, C.J., Weng, N.Y. Dev. Cell (2001) [Pubmed]
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