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MeSH Review

Cell Movement

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Disease relevance of Cell Movement


Psychiatry related information on Cell Movement


High impact information on Cell Movement


Chemical compound and disease context of Cell Movement


Biological context of Cell Movement


Anatomical context of Cell Movement


Associations of Cell Movement with chemical compounds

  • Peripheral neuronal subpopulations expressing the TrkC receptor tyrosine kinase respond to Nt3 with enhanced survival, mitogenesis or cell migration and these neurons are lost in homozygous Nt3 null (-/-) mutant mice [30].
  • Effects of LETS glycoprotein on cell motility [31].
  • The receptor binds immobilized discoidin I in the presence of 0.3 M galactose and can be eluted with gly-arg-gly-asp-his-asp, a synthetic peptide the sequence of which is found in discoidin I, and which blocks cell migration into aggregates [32].
  • The finding of this type of coactivator required for cell motility suggests a novel role for steroid hormones, in stimulating invasive cell behavior, independent of effects on proliferation [33].
  • Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility [34].

Gene context of Cell Movement

  • These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals [35].
  • In C. elegans, CED-12 is required for engulfment of dying cells and for cell migrations [35].
  • Guidance of cell migration by the Drosophila PDGF/VEGF receptor [36].
  • unc-73 is required for cell migrations and axon guidance in C. elegans and encodes overlapping isoforms of 283 and 189 kDa that are closely related to the vertebrate Trio and Kalirin proteins, respectively [37].
  • In higher eukaryotes, the small GTPase Cdc42, acting through a Par6-atypical protein kinase C (aPKC) complex, is required to establish cellular asymmetry during epithelial morphogenesis, asymmetric cell division and directed cell migration [38].

Analytical, diagnostic and therapeutic context of Cell Movement


  1. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang, J., Mani, S.A., Donaher, J.L., Ramaswamy, S., Itzykson, R.A., Come, C., Savagner, P., Gitelman, I., Richardson, A., Weinberg, R.A. Cell (2004) [Pubmed]
  2. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Streblow, D.N., Soderberg-Naucler, C., Vieira, J., Smith, P., Wakabayashi, E., Ruchti, F., Mattison, K., Altschuler, Y., Nelson, J.A. Cell (1999) [Pubmed]
  3. Alteration of the chemotactic response of NIH/3T3 cells to PDGF by growth factors, transformation, and tumor promoters. Grotendorst, G.R. Cell (1984) [Pubmed]
  4. The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Näthke, I.S. Annu. Rev. Cell Dev. Biol. (2004) [Pubmed]
  5. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Hojo, M., Morimoto, T., Maluccio, M., Asano, T., Morimoto, K., Lagman, M., Shimbo, T., Suthanthiran, M. Nature (1999) [Pubmed]
  6. Expression of CAP37, a novel inflammatory mediator, in Alzheimer's disease. Pereira, H.A., Kumar, P., Grammas, P. Neurobiol. Aging (1996) [Pubmed]
  7. Repeated morphine treatment alters polysialylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and cell proliferation in the adult rat hippocampus. Kahn, L., Alonso, G., Normand, E., Manzoni, O.J. Eur. J. Neurosci. (2005) [Pubmed]
  8. Neuronal migration in developmental disorders. McManus, M.F., Golden, J.A. J. Child Neurol. (2005) [Pubmed]
  9. Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). Zimmermann, A., Keller, H. Anticancer Res. (1993) [Pubmed]
  10. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Cyster, J.G. Annu. Rev. Immunol. (2005) [Pubmed]
  11. Integrins and T cell-mediated immunity. Pribila, J.T., Quale, A.C., Mueller, K.L., Shimizu, Y. Annu. Rev. Immunol. (2004) [Pubmed]
  12. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Foo, S.S., Turner, C.J., Adams, S., Compagni, A., Aubyn, D., Kogata, N., Lindblom, P., Shani, M., Zicha, D., Adams, R.H. Cell (2006) [Pubmed]
  13. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Boire, A., Covic, L., Agarwal, A., Jacques, S., Sherifi, S., Kuliopulos, A. Cell (2005) [Pubmed]
  14. A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration. Geisbrecht, E.R., Montell, D.J. Cell (2004) [Pubmed]
  15. Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. Nieto, M., Frade, J.M., Sancho, D., Mellado, M., Martinez-A, C., Sánchez-Madrid, F. J. Exp. Med. (1997) [Pubmed]
  16. Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling. Sumitomo, M., Shen, R., Walburg, M., Dai, J., Geng, Y., Navarro, D., Boileau, G., Papandreou, C.N., Giancotti, F.G., Knudsen, B., Nanus, D.M. J. Clin. Invest. (2000) [Pubmed]
  17. A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion. Faassen, A.E., Schrager, J.A., Klein, D.J., Oegema, T.R., Couchman, J.R., McCarthy, J.B. J. Cell Biol. (1992) [Pubmed]
  18. (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase. Sperl, S., Jacob, U., Arroyo de Prada, N., Stürzebecher, J., Wilhelm, O.G., Bode, W., Magdolen, V., Huber, R., Moroder, L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Yamauchi, J., Miyamoto, Y., Tanoue, A., Shooter, E.M., Chan, J.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  20. Paxillin: adapting to change. Brown, M.C., Turner, C.E. Physiol. Rev. (2004) [Pubmed]
  21. PKB binding proteins. Getting in on the Akt. Brazil, D.P., Park, J., Hemmings, B.A. Cell (2002) [Pubmed]
  22. Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Colvin, J.S., Green, R.P., Schmahl, J., Capel, B., Ornitz, D.M. Cell (2001) [Pubmed]
  23. Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth. Condic, M.L., Letourneau, P.C. Nature (1997) [Pubmed]
  24. A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Forrester, W.C., Dell, M., Perens, E., Garriga, G. Nature (1999) [Pubmed]
  25. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., Soriano, P. Cell (1996) [Pubmed]
  26. A homing receptor-bearing cortical thymocyte subset: implications for thymus cell migration and the nature of cortisone-resistant thymocytes. Reichert, R.A., Gallatin, W.M., Butcher, E.C., Weissman, I.L. Cell (1984) [Pubmed]
  27. Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Krause, M., Dent, E.W., Bear, J.E., Loureiro, J.J., Gertler, F.B. Annu. Rev. Cell Dev. Biol. (2003) [Pubmed]
  28. Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Moos, M., Tacke, R., Scherer, H., Teplow, D., Früh, K., Schachner, M. Nature (1988) [Pubmed]
  29. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Hamelin, M., Zhou, Y., Su, M.W., Scott, I.M., Culotti, J.G. Nature (1993) [Pubmed]
  30. Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Donovan, M.J., Hahn, R., Tessarollo, L., Hempstead, B.L. Nat. Genet. (1996) [Pubmed]
  31. Effects of LETS glycoprotein on cell motility. Ali, I.U., Hynes, R.O. Cell (1978) [Pubmed]
  32. Receptor for the cell binding site of discoidin I. Gabius, H.J., Springer, W.R., Barondes, S.H. Cell (1985) [Pubmed]
  33. Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer. Bai, J., Uehara, Y., Montell, D.J. Cell (2000) [Pubmed]
  34. Lymphocyte activation by HIV-1 envelope glycoprotein. Kornfeld, H., Cruikshank, W.W., Pyle, S.W., Berman, J.S., Center, D.M. Nature (1988) [Pubmed]
  35. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Gumienny, T.L., Brugnera, E., Tosello-Trampont, A.C., Kinchen, J.M., Haney, L.B., Nishiwaki, K., Walk, S.F., Nemergut, M.E., Macara, I.G., Francis, R., Schedl, T., Qin, Y., Van Aelst, L., Hengartner, M.O., Ravichandran, K.S. Cell (2001) [Pubmed]
  36. Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Duchek, P., Somogyi, K., Jékely, G., Beccari, S., Rørth, P. Cell (2001) [Pubmed]
  37. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Steven, R., Kubiseski, T.J., Zheng, H., Kulkarni, S., Mancillas, J., Ruiz Morales, A., Hogue, C.W., Pawson, T., Culotti, J. Cell (1998) [Pubmed]
  38. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Etienne-Manneville, S., Hall, A. Nature (2003) [Pubmed]
  39. Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Guo, L., Degenstein, L., Dowling, J., Yu, Q.C., Wollmann, R., Perman, B., Fuchs, E. Cell (1995) [Pubmed]
  40. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Weber, G.F., Ashkar, S., Glimcher, M.J., Cantor, H. Science (1996) [Pubmed]
  41. BCR/ABL induces multiple abnormalities of cytoskeletal function. Salgia, R., Li, J.L., Ewaniuk, D.S., Pear, W., Pisick, E., Burky, S.A., Ernst, T., Sattler, M., Chen, L.B., Griffin, J.D. J. Clin. Invest. (1997) [Pubmed]
  42. Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration. Noguchi, T., Matozaki, T., Inagaki, K., Tsuda, M., Fukunaga, K., Kitamura, Y., Kitamura, T., Shii, K., Yamanashi, Y., Kasuga, M. EMBO J. (1999) [Pubmed]
  43. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. Stipp, C.S., Litwack, E.D., Lander, A.D. J. Cell Biol. (1994) [Pubmed]
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