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Gene Review:

Sypl2 - synaptophysin-like 2

Mus musculus

Synonyms: AI552439, Mg29, Mitsugumin-29, Synaptophysin-like protein 2

Brotto, M.A. et al., Nagaraj, R.Y. et al., Pan, Z. et al.

Brotto, Nagaraj, Brotto, Takeshima, Ma, Nosek,

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High impact information on Sypl2

Here, we identify SOC in skeletal muscle and characterise its regulation by MG29 and the ryanodine receptor (RyR) located in the SR [1].
Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice [2].
Mitsugumin 29 (MG29) is a transmembrane protein that is normally found in the triad junction of skeletal muscle [2].
We carried out several experiments to not only study the role of MG29 in normal muscle contraction but also to determine its role in muscle fatigue [3].

References

Dysfunction of store-operated calcium channel in muscle cells lacking mg29. Pan, Z., Yang, D., Nagaraj, R.Y., Nosek, T.A., Nishi, M., Takeshima, H., Cheng, H., Ma, J. Nat. Cell Biol. (2002) [Pubmed]
Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice. Brotto, M.A., Nagaraj, R.Y., Brotto, L.S., Takeshima, H., Ma, J.J., Nosek, T.M. Cell Res. (2004) [Pubmed]
Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene. Nagaraj, R.Y., Nosek, C.M., Brotto, M.A., Nishi, M., Takeshima, H., Nosek, T.M., Ma, J. Physiol. Genomics (2000) [Pubmed]

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