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MeSH Review

Muscle Contraction

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Disease relevance of Muscle Contraction


Psychiatry related information on Muscle Contraction


High impact information on Muscle Contraction


Chemical compound and disease context of Muscle Contraction


Biological context of Muscle Contraction


Anatomical context of Muscle Contraction


Associations of Muscle Contraction with chemical compounds

  • In the American lobster, octopamine produces an increase in muscular tension during activation of the motor nerve and may induce spontaneous contractions at concentrations of 10(-7) M (refs 1,2) [31].
  • GABA(A) (gamma-aminobutyric acid(A)) receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity and memory functions, which is evident from the spectrum of actions elicited by clinically effective drugs acting at their modulatory benzodiazepine-binding site [32].
  • Calcium ions activate muscle contraction [33].
  • Anxiety and muscle tension as consequences of caffeine withdrawal [34].
  • These data indicate that AMPK transmits a portion of the signal by which muscle contraction increases glucose uptake, but other AMPK-independent pathways also contribute to the response [35].

Gene context of Muscle Contraction


Analytical, diagnostic and therapeutic context of Muscle Contraction

  • GABAA receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity, and memory functions, and the enhancement of GABAA receptor-mediated fast synaptic inhibition is the basis for the pharmacotherapy of various neurological and psychiatric disorders [41].
  • The postarteriolar response of capillary transport and microvascular flow distribution to muscle contraction and to adenosine was measured by the indicator dilution technique in isolated dog gracilis muscles perfused with blood at controlled flows [42].
  • By using as bioassay an isolated and perfused frog (Rana esculenta) heart preparation, we show here that HCNP acts on the cardiac mechanical performance exerting a negative inotropism and counteracting the adrenergic stimulation of isoproterenol [43].
  • NMR spectroscopy and selective isotope labeling of both recombinant cardiac troponin C (cTnC3) and a truncated cardiac troponin I (cTnI/NH2) lacking the N-terminal 32-amino acid cardiac-specific sequence have been used to probe protein-protein interactions central to muscle contraction [44].
  • RESULTS: Biofeedback and relaxation were associated with significant decreases in average blood glucose, A1C, and muscle tension compared with the control group [45].


  1. Human gene for torsion dystonia located on chromosome 9q32-q34. Ozelius, L., Kramer, P.L., Moskowitz, C.B., Kwiatkowski, D.J., Brin, M.F., Bressman, S.B., Schuback, D.E., Falk, C.T., Risch, N., de Leon, D. Neuron (1989) [Pubmed]
  2. Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model. Dodd, D.A., Atkinson, J.B., Olson, R.D., Buck, S., Cusack, B.J., Fleischer, S., Boucek, R.J. J. Clin. Invest. (1993) [Pubmed]
  3. Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation. Zierath, J.R., Tsao, T.S., Stenbit, A.E., Ryder, J.W., Galuska, D., Charron, M.J. J. Biol. Chem. (1998) [Pubmed]
  4. Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle. Ver Donck, L., Borgers, M., Verdonck, F. Cardiovasc. Res. (1993) [Pubmed]
  5. Effects of acutely raising intracranial pressure on cardiac sympathetic efferent neuron function. Murphy, D.A., O'Blenes, S., Nassar, B.A., Armour, J.A. Cardiovasc. Res. (1995) [Pubmed]
  6. Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT2A receptor responsivity. Bull, E.J., Hutson, P.H., Fone, K.C. Neuropharmacology (2004) [Pubmed]
  7. The effects of nicotine chewing gum on the sensitivity to muscle tension. Russell, P.O., Epstein, L.H., Sittenfield, S.L., Block, D.R. Psychopharmacology (Berl.) (1986) [Pubmed]
  8. Neuroleptic malignant syndrome and mivacurium: a safe alternative to succinylcholine? Kelly, D., Brull, S.J. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1994) [Pubmed]
  9. Relationship between sleep, neck muscle activity, and pain in cervical dystonia. Lobbezoo, F., Thu Thon, M., Rémillard, G., Montplaisir, J.Y., Lavigne, G.J. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1996) [Pubmed]
  10. Multiple lineage specific expansions within the guanylyl cyclase gene family. Fitzpatrick, D.A., O'Halloran, D.M., Burnell, A.M. BMC Evol. Biol. (2006) [Pubmed]
  11. Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. Littleton, J.T., Stern, M., Schulze, K., Perin, M., Bellen, H.J. Cell (1993) [Pubmed]
  12. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. Bristow, M.R., Ginsburg, R., Minobe, W., Cubicciotti, R.S., Sageman, W.S., Lurie, K., Billingham, M.E., Harrison, D.C., Stinson, E.B. N. Engl. J. Med. (1982) [Pubmed]
  13. Arp2/3 plays no role in muscle contraction. Pollard, T.D., Hanein, D., Volkmann, N. Nature (2002) [Pubmed]
  14. Structure and regulation of voltage-gated Ca2+ channels. Catterall, W.A. Annu. Rev. Cell Dev. Biol. (2000) [Pubmed]
  15. Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction. Corrie, J.E., Brandmeier, B.D., Ferguson, R.E., Trentham, D.R., Kendrick-Jones, J., Hopkins, S.C., van der Heide, U.A., Goldman, Y.E., Sabido-David, C., Dale, R.E., Criddle, S., Irving, M. Nature (1999) [Pubmed]
  16. Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4. Gulve, E.A., Ren, J.M., Marshall, B.A., Gao, J., Hansen, P.A., Holloszy, J.O., Mueckler, M. J. Biol. Chem. (1994) [Pubmed]
  17. Ischaemic skeletal muscle hyperaemia in the anaesthetized cat: no contribution of A2A adenosine receptors. Poucher, S.M. J. Physiol. (Lond.) (1997) [Pubmed]
  18. Platelet activation in muscle contraction headache and migraine. Takeshima, T., Shimomura, T., Takahashi, K. Cephalalgia : an international journal of headache. (1987) [Pubmed]
  19. Alpha-dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy. Ervasti, J.M., Roberds, S.L., Anderson, R.D., Sharp, N.J., Kornegay, J.N., Campbell, K.P. FEBS Lett. (1994) [Pubmed]
  20. Antioxidant properties of pyruvate mediate its potentiation of beta-adrenergic inotropism in stunned myocardium. Tejero-Taldo, M.I., Caffrey, J.L., Sun, J., Mallet, R.T. J. Mol. Cell. Cardiol. (1999) [Pubmed]
  21. Creatine kinase role in anaphase chromosome movement. Cande, W.Z. Nature (1983) [Pubmed]
  22. Role of intracellular sodium in the regulation of intracellular calcium and contractility. Effects of DPI 201-106 on excitation-contraction coupling in human ventricular myocardium. Gwathmey, J.K., Slawsky, M.T., Briggs, G.M., Morgan, J.P. J. Clin. Invest. (1988) [Pubmed]
  23. Myosin light chain-2 mutation affects flight, wing beat frequency, and indirect flight muscle contraction kinetics in Drosophila. Warmke, J., Yamakawa, M., Molloy, J., Falkenthal, S., Maughan, D. J. Cell Biol. (1992) [Pubmed]
  24. The Caenorhabditis elegans UNC-87 protein is essential for maintenance, but not assembly, of bodywall muscle. Goetinck, S., Waterston, R.H. J. Cell Biol. (1994) [Pubmed]
  25. Intracellular high-energy phosphate transfer in normal and hypertrophied myocardium. Bittl, J.A., Ingwall, J.S. Circulation (1987) [Pubmed]
  26. A single myosin head moves along an actin filament with regular steps of 5.3 nanometres. Kitamura, K., Tokunaga, M., Iwane, A.H., Yanagida, T. Nature (1999) [Pubmed]
  27. Positive inotropism of vanadate in cat papillary muscle. Hackbarth, I., Schmitz, W., Scholz, H., Erdmann, E., Krawietz, W., Philipp, G. Nature (1978) [Pubmed]
  28. Myoblast fusion and innervation with rat motor nerve alter distribution of acetylcholinesterase and its mRNA in cultures of human muscle. Grubic, Z., Komel, R., Walker, W.F., Miranda, A.F. Neuron (1995) [Pubmed]
  29. Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. Kiens, B., Lithell, H., Mikines, K.J., Richter, E.A. J. Clin. Invest. (1989) [Pubmed]
  30. Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation. Liu, H., Mardahl-Dumesnil, M., Sweeney, S.T., O'Kane, C.J., Bernstein, S.I. J. Cell Biol. (2003) [Pubmed]
  31. Octopamine--a neurohormone with presynaptic activity-dependent effects at crayfish neuromuscular junctions. Breen, C.A., Atwood, H.L. Nature (1983) [Pubmed]
  32. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J.A., Fritschy, J.M., Martin, J.R., Bluethmann, H., Möhler, H. Nature (1999) [Pubmed]
  33. Hysteresis in the force-calcium relation in muscle. Ridgway, E.B., Gordon, A.M., Martyn, D.A. Science (1983) [Pubmed]
  34. Anxiety and muscle tension as consequences of caffeine withdrawal. White, B.C., Lincoln, C.A., Pearce, N.W., Reeb, R., Vaida, C. Science (1980) [Pubmed]
  35. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mu, J., Brozinick, J.T., Valladares, O., Bucan, M., Birnbaum, M.J. Mol. Cell (2001) [Pubmed]
  36. The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction. Levin, J.Z., Horvitz, H.R. J. Cell Biol. (1992) [Pubmed]
  37. Mdm muscular dystrophy: interactions with calpain 3 and a novel functional role for titin's N2A domain. Huebsch, K.A., Kudryashova, E., Wooley, C.M., Sher, R.B., Seburn, K.L., Spencer, M.J., Cox, G.A. Hum. Mol. Genet. (2005) [Pubmed]
  38. Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1. Ryder, J.W., Fahlman, R., Wallberg-Henriksson, H., Alessi, D.R., Krook, A., Zierath, J.R. J. Biol. Chem. (2000) [Pubmed]
  39. Protein phosphatase 1beta is required for the maintenance of muscle attachments. Raghavan, S., Williams, I., Aslam, H., Thomas, D., Szöor, B., Morgan, G., Gross, S., Turner, J., Fernandes, J., VijayRaghavan, K., Alphey, L. Curr. Biol. (2000) [Pubmed]
  40. Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle. Nongthomba, U., Clark, S., Cummins, M., Ansari, M., Stark, M., Sparrow, J.C. J. Cell. Sci. (2004) [Pubmed]
  41. Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Rudolph, U., Möhler, H. Annu. Rev. Pharmacol. Toxicol. (2004) [Pubmed]
  42. Effects of muscle contraction and of adenosine on capillary transport and microvascular flow in dog skeletal muscle. Durán, W.N. Circ. Res. (1977) [Pubmed]
  43. The hippocampal cholinergic neurostimulating peptide, the N-terminal fragment of the secreted phosphatidylethanolamine-binding protein, possesses a new biological activity on cardiac physiology. Goumon, Y., Angelone, T., Schoentgen, F., Chasserot-Golaz, S., Almas, B., Fukami, M.M., Langley, K., Welters, I.D., Tota, B., Aunis, D., Metz-Boutigue, M.H. J. Biol. Chem. (2004) [Pubmed]
  44. NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex. Krudy, G.A., Kleerekoper, Q., Guo, X., Howarth, J.W., Solaro, R.J., Rosevear, P.R. J. Biol. Chem. (1994) [Pubmed]
  45. Biofeedback-assisted relaxation in type 2 diabetes. McGinnis, R.A., McGrady, A., Cox, S.A., Grower-Dowling, K.A. Diabetes Care (2005) [Pubmed]
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